Cysltr1 - cysteinyl leukotriene receptor 1 Gene

Also Known as Cyslt1; CysLT1R

Species: Mus musculus

Gene Type: protein coding
Gene ID: 58861

About Cysltr1

Chromosome X: 105,617,952-105,647,285 reverse strand.GRCm39:CM001013.3

This gene has 2 transcripts (splice variants), 177 orthologues, 16 paralogues and is associated with 10 phenotypes. Broad expression in placenta adult (RPKM 1.9), bladder adult (RPKM 1.) and 18 other tissues.

Summary

Enables Leukotriene Receptor activity. Acts upstream of or within several processes, including calcium ion transport; chemotaxis; and inflammatory response to antigenic stimulus. Is integral component of plasma membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in allergic disease; asthma; and rhinitis. Orthologous to human CYSLTR1 (cysteinyl Leukotriene Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Cysltr1 Products (3)

mRNA Protein Name
NM_001281859.1 NP_001268788.1 cysteinyl leukotriene receptor 1 isoform a
NM_001281862.1 NP_001268791.1 cysteinyl leukotriene receptor 1 isoform b
NM_021476.5 NP_067451.2 cysteinyl leukotriene receptor 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables leukotriene receptor activity IDA
IDA: Inferred from direct assay
11226226 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19561298 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion transport IDA
IDA: Inferred from direct assay
16002666 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
11226226 MGI
acts upstream of or within chemotaxis IDA
IDA: Inferred from direct assay
16002666 MGI
acts upstream of or within establishment of localization in cell IDA
IDA: Inferred from direct assay
16002666 MGI
acts upstream of or within inflammatory response to antigenic stimulus IMP
IMP: Inferred from mutant phenotype
20574000 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
11226226 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cysltr1 Protein Structure

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (38 - 65)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (38 - 320)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (72 - 97)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (110 - 140)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (152 - 174)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (200 - 229)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (240 - 270)

7tmA_CysLTR1

7tmA_CysLTR1: cd15158 (288 - 313)

  • 0
  • 100
  • 200
  • 300
  • 352 a.a.
Protein Preferred Names Protein Names

cysteinyl leukotriene receptor 1

  • LTD4 receptor

  • cysteinyl leukotriene D4 receptor

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13315A Montelukast Antagonist 99.94% Yes
HY-13315 Montelukast sodium Antagonist 99.84% Yes
HY-13315B Montelukast dicyclohexylamine Antagonist / Unkown

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13315S1 Montelukast-d6 sodium Antagonist ≥96.0% Unkown
HY-13315S Montelukast-d6 Antagonist / Unkown
HY-19395 MEN-91507 Antagonist / Unkown
HY-RS03494 CYSLTR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03495 Cysltr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03496 Cysltr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cysltr1 NCBI NCBI:10800