MOK - MOK protein kinase Gene

Homo sapiens

Also known as RAGE; RAGE1; STK30; RAGE-1

Gene ID: 5891 | Gene type: protein coding

About MOK

Cytogenetic location: 14q32.31 Genomic coordinates (GRCh38): 14:102,214,596-102,305,164 (from NCBI)

This gene has 40 transcripts (splice variants), 196 orthologues and 19 paralogues. Broad expression in testis (RPKM 9.4), thyroid (RPKM 2.1) and 15 other tissues.

Summary

This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

MOK Products(9)

mRNA	Protein	Name
NM_001272011.2	NP_001258940.1	MAPK/MAK/MRK overlapping kinase isoform 2
NM_001330234.2	NP_001317163.1	MAPK/MAK/MRK overlapping kinase isoform 3
NM_001353827.2	NP_001340756.1	MAPK/MAK/MRK overlapping kinase isoform 4
NM_001353828.2	NP_001340757.1	MAPK/MAK/MRK overlapping kinase isoform 5
NM_001353829.2	NP_001340758.1	MAPK/MAK/MRK overlapping kinase isoform 6
NM_001353830.2	NP_001340759.1	MAPK/MAK/MRK overlapping kinase isoform 7
NM_001353831.2	NP_001340760.1	MAPK/MAK/MRK overlapping kinase isoform 8
NM_001353832.2	NP_001340761.1	MAPK/MAK/MRK overlapping kinase isoform 9
NM_014226.3	NP_055041.1	MAPK/MAK/MRK overlapping kinase isoform 1

MOK Protein Structure

Pkinase

0
100
200
300
419 a.a.

Protein Preferred Names

Protein Names

MAPK/MAK/MRK overlapping kinase

renal cell carcinoma antigen

Related Diseases

Diseases

Alias

Endocrine-Cerebroosteodysplasia

Endocrine-Cerebro-Osteodysplasia Syndrome	ECO
Eco Syndrome

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08586	MOK Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MOK	MGD	MGI:1336881
Macaca mulatta	MOK	VGNC	VGNC:84394
Rattus norvegicus	MOK	RGD	RGD:1309274
Canis familiaris	MOK	VGNC	VGNC:43312
Bos taurus	MOK	VGNC	VGNC:31551
Felis catus	MOK	VGNC	VGNC:69223
Macaca fascicularis	MOK	NCBI
Canis lupus familiaris	MOK	NCBI
Susscrofa domestica	MOK	NCBI
Leporidae	MOK	NCBI
Others	MOK	NCBI