MOK - MOK protein kinase Gene

Also Known as RAGE; RAGE1; STK30; RAGE-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5891

About MOK

Cytogenetic location: 14q32.31 Genomic coordinates (GRCh38): 14:102,214,596-102,305,164 (from NCBI)

This gene has 40 transcripts (splice variants), 196 orthologues and 19 paralogues. Broad expression in testis (RPKM 9.4), thyroid (RPKM 2.1) and 15 other tissues.

Summary

This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

MOK Products (9)

mRNA Protein Name
NM_001272011.2 NP_001258940.1 MAPK/MAK/MRK overlapping kinase isoform 2
NM_001330234.2 NP_001317163.1 MAPK/MAK/MRK overlapping kinase isoform 3
NM_001353827.2 NP_001340756.1 MAPK/MAK/MRK overlapping kinase isoform 4
NM_001353828.2 NP_001340757.1 MAPK/MAK/MRK overlapping kinase isoform 5
NM_001353829.2 NP_001340758.1 MAPK/MAK/MRK overlapping kinase isoform 6
NM_001353830.2 NP_001340759.1 MAPK/MAK/MRK overlapping kinase isoform 7
NM_001353831.2 NP_001340760.1 MAPK/MAK/MRK overlapping kinase isoform 8
NM_001353832.2 NP_001340761.1 MAPK/MAK/MRK overlapping kinase isoform 9
NM_014226.3 NP_055041.1 MAPK/MAK/MRK overlapping kinase isoform 1

MOK Protein Structure

Pkinase

Pkinase: Protein kinase domain (4 - 285)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 419 a.a.
Protein Preferred Names Protein Names

MAPK/MAK/MRK overlapping kinase

  • renal cell carcinoma antigen

Related Diseases

Diseases Alias
Endocrine-Cerebroosteodysplasia

  • Endocrine-Cerebro-Osteodysplasia Syndrome

  • ECO

  • Eco Syndrome
Noonan Syndrome 1

  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16906 T338C Src-IN-2 Inhibitor 98.41% Unkown
HY-181586 CK1γ-IN-1 Inhibitor / Unkown
HY-RS08586 MOK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16907 Mok Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23349 Mok Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MOK MGD MGI:1336881
Macaca mulatta MOK VGNC VGNC:84394
Rattus norvegicus MOK RGD RGD:1309274
Canis familiaris MOK VGNC VGNC:43312
Bos taurus MOK VGNC VGNC:31551
Felis catus MOK VGNC VGNC:69223
Others MOK NCBI