Ghrl - ghrelin Gene

Also Known as Ghr; m46; MTLRP; MTLRPAP; 2210006E23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 58991

Summary

This gene encodes a preproprotein that undergoes proteolytic processing to yield two bioactive peptides, ghrelin and obestatin. The hormone ghrelin plays a role in enhancing appetite and has numerous Other biological functions that include stimulating the secretion of growth hormone (somatotropin) from the anterior pituitary gland. Obestatin is thought to be a hormone that functions in decreasing appetite. Mice lacking the encoded protein develop normally and exhibit no gross anatomical abnormalities. This gene encodes distinct isoforms, some or all of which may undergo similar proteolytic processing. [provided by RefSeq, Jul 2016]

Ghrl Products (5)

mRNA Protein Name
NM_001286404.1 NP_001273333.1 appetite-regulating hormone isoform 2 preproprotein
NM_001286405.1 NP_001273334.1 appetite-regulating hormone isoform 3 precursor
NM_001286406.1 NP_001273335.1 appetite-regulating hormone isoform 4 precursor
NM_001379129.1 NP_001366058.1 appetite-regulating hormone isoform 1 preproprotein
NM_021488.5 NP_067463.2 appetite-regulating hormone isoform 1 preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in adult feeding behavior IDA
IDA: Inferred from direct assay
16322794 MGI
acts upstream of or within dendrite development IMP
IMP: Inferred from mutant phenotype
16491079 MGI
acts upstream of or within excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
16491079 MGI
acts upstream of or within negative regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
17130496 MGI
acts upstream of or within negative regulation of locomotion IMP
IMP: Inferred from mutant phenotype
16322795 MGI
acts upstream of or within positive regulation of appetite IDA
IDA: Inferred from direct assay
15070777 MGI
involved in positive regulation of appetite IDA
IDA: Inferred from direct assay
16322794 MGI
acts upstream of or within positive regulation of appetite IGI
IGI: Inferred from genetic interaction
15070777 MGI
NOT acts upstream of or within positive regulation of appetite IMP
IMP: Inferred from mutant phenotype
14585959 MGI
acts upstream of or within positive regulation of appetite IMP
IMP: Inferred from mutant phenotype
17060947 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
19666521 MGI
acts upstream of or within positive regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
16491079 MGI
acts upstream of synapse assembly IMP
IMP: Inferred from mutant phenotype
16491079 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10930375 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
10930375 MGI
is active in neuronal dense core vesicle lumen IDA
IDA: Inferred from direct assay
12597862 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

appetite-regulating hormone

  • growth hormone secretagogue

  • growth hormone-releasing peptide

  • motilin-related peptide

  • preproghrelin

  • proghrelin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05415 GHRL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20741 Ghrl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27253 Ghrl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ghrl NCBI NCBI:51738