Grk6 - G protein-coupled receptor kinase 6 Gene

Also Known as Gprk6

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 59076

Summary

Enables G protein-coupled receptor kinase activity. Involved in several processes, including cellular response to lipopolysaccharide; desensitization of G protein-coupled receptor signaling pathway; and negative regulation of anion channel activity. Located in cytosol and plasma membrane. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GRK6 (G protein-coupled receptor kinase 6). [provided by Alliance of Genome Resources, Apr 2022]

Grk6 Products (3)

mRNA Protein Name
NM_001112712.2 NP_001106183.1 G protein-coupled receptor kinase 6 isoform c
NM_001112713.1 NP_001106184.1 G protein-coupled receptor kinase 6 isoform b
NM_031657.4 NP_113845.2 G protein-coupled receptor kinase 6 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor kinase activity IDA
IDA: Inferred from direct assay
12810562 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
23359120 RGD
involved in desensitization of G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
12810562 RGD
involved in desensitization of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17908240 RGD
involved in negative regulation of anion channel activity IMP
IMP: Inferred from mutant phenotype
17170521 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12810562 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

G protein-coupled receptor kinase 6

  • g protein-coupled receptor kinase GRK6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-142817 GRK6/Aurora A-IN-1 Inhibitor 98.98% Unkown
HY-180583 GRK5-IN-5 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grk6 NCBI NCBI:2870