Ghrl - ghrelin and obestatin prepropeptide Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 59301

Summary

Enables ghrelin receptor binding activity and growth hormone-releasing hormone activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of peptide hormone secretion; and regulation of digestive system process. Acts upstream of or within negative regulation of Insulin secretion. Located in cytoplasm. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Used to study middle cerebral artery infarction. Biomarker of multiple endocrine neoplasia and obstructive sleep apnea. Human ortholog(s) of this gene implicated in diabetic neuropathy; esophagus adenocarcinoma; morbid obesity; obesity; and type 2 diabetes mellitus. Orthologous to human GHRL (ghrelin and obestatin prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]

Ghrl Products (1)

mRNA Protein Name
NM_021669.2 NP_067701.1 appetite-regulating hormone preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor binding IPI
IPI: Inferred from physical interaction
10604470 RGD
enables ghrelin receptor binding IMP
IMP: Inferred from mutant phenotype
17109695 RGD
enables growth hormone-releasing hormone activity IDA
IDA: Inferred from direct assay
10604470 RGD
enables hormone activity IDA
IDA: Inferred from direct assay
17109695 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
10604470 RGD
involved in gastric acid secretion IDA
IDA: Inferred from direct assay
17705669 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
17543279 RGD
acts upstream of or within negative regulation of insulin secretion IDA
IDA: Inferred from direct assay
17130496 RGD
involved in negative regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
19620309 RGD
involved in negative regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
19620309 RGD
involved in positive regulation of adipose tissue development IDA
IDA: Inferred from direct assay
14551228 RGD
involved in positive regulation of appetite IMP
IMP: Inferred from mutant phenotype
15994217 RGD
involved in positive regulation of bone development IDA
IDA: Inferred from direct assay
12960077 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
11756331 RGD
involved in positive regulation of eating behavior IDA
IDA: Inferred from direct assay
14551228 RGD
involved in positive regulation of feeding behavior IDA
IDA: Inferred from direct assay
17033095 RGD
involved in positive regulation of gastric mucosal blood circulation IDA
IDA: Inferred from direct assay
17033095 RGD
involved in positive regulation of gastro-intestinal system smooth muscle contraction IDA
IDA: Inferred from direct assay
15890336 RGD
involved in positive regulation of growth IDA
IDA: Inferred from direct assay
12960077 RGD
involved in positive regulation of growth hormone secretion IDA
IDA: Inferred from direct assay
10604470 RGD
involved in positive regulation of growth rate IDA
IDA: Inferred from direct assay
17033095 RGD
involved in positive regulation of insulin secretion IDA
IDA: Inferred from direct assay
11756331 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
16647196 RGD
involved in positive regulation of response to food IDA
IDA: Inferred from direct assay
17065340 RGD
involved in positive regulation of small intestinal transit IDA
IDA: Inferred from direct assay
21874246 RGD
involved in positive regulation of small intestine smooth muscle contraction IDA
IDA: Inferred from direct assay
15890336 RGD
involved in positive regulation of sprouting angiogenesis IDA
IDA: Inferred from direct assay
21642627 RGD
involved in positive regulation of vascular endothelial cell proliferation IDA
IDA: Inferred from direct assay
21642627 RGD
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
26153524 RGD
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
26153524 RGD
involved in regulation of gastric motility IDA
IDA: Inferred from direct assay
23525979 RGD
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
22516464 RGD
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
22516464 RGD
involved in regulation of response to food IDA
IDA: Inferred from direct assay
17065340 RGD
involved in regulation of transmission of nerve impulse IDA
IDA: Inferred from direct assay
23525979 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
23525979 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
26512025 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
26153524 RGD
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
26153524 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
22516464 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
22516464 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

appetite-regulating hormone

  • ghrelin/obestatin prepropeptide

  • growth hormone secretagogue

  • growth hormone-releasing peptide

  • motilin-related peptide

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05415 GHRL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20741 Ghrl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27253 Ghrl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ghrl NCBI NCBI:51738