Shank3 - SH3 and multiple ankyrin repeat domains 3 Gene

Also Known as Prosap2; Spank-2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 59312

Summary

Enables several functions, including SH3 domain binding activity; protein C-terminus binding activity; and scaffold protein binding activity. A structural constituent of postsynaptic density. Involved in positive regulation of glutamate receptor signaling pathway and regulation of synapse organization. Located in ciliary membrane and synapse. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Used to study Phelan-McDermid syndrome. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome and schizophrenia 15. Orthologous to human SHANK3 (SH3 and multiple ankyrin repeat domains 3). [provided by Alliance of Genome Resources, Apr 2022]

Shank3 Products (1)

mRNA	Protein	Name
NM_021676.3	NP_067708.2	SH3 and multiple ankyrin repeat domains protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	10958799	RGD
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	15014124	RGD
enables identical protein binding	IDA IDA: Inferred from direct assay	16439662	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	10433268	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10433269	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	16439662	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	10433269	RGD
enables structural constituent of postsynaptic density	IDA IDA: Inferred from direct assay	10433269	RGD
enables structural constituent of postsynaptic density	IMP IMP: Inferred from mutant phenotype	21217644	RGD
enables synaptic receptor adaptor activity	IDA IDA: Inferred from direct assay	10433269	RGD
enables zinc ion binding	IDA IDA: Inferred from direct assay	16439662	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of glutamate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21795692	RGD
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	21217644	RGD
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	21217644	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in ciliary membrane	IDA IDA: Inferred from direct assay	18596612	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	10433269	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21217644	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	23719161	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	10433269	RGD
is active in postsynaptic density	IMP IMP: Inferred from mutant phenotype	23719161	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	15894489	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
SH3 and multiple ankyrin repeat domains protein 3	SH3/ankyrin domain gene 3 Shank postsynaptic density protein 3a proline-rich synapse-associated protein 2

Shank3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Shank3	Q9JLU4	Arhgef7	Rattus norvegicus	O55043	Anti Bait CoIP	12626503
Intra	Shank3	Q9JLU4	Abi1	Rattus norvegicus	Q9QZM5	Anti Bait CoIP	17304222
Intra	Shank3	Q9JLU4	Camk2a	Mus musculus	P11798	Anti Tag CoIP	28130356
Intra	Shank3	Q9JLU4	Shank3	Rattus norvegicus	Q9JLU4	Pull Down	10433268
Intra	Shank3	Q9JLU4	Rps6ka2	Mus musculus	Q9WUT3	Y2H	16217014
Intra	Shank3	Q9JLU4	Abi1	Rattus norvegicus	Q9QZM5	Pull Down	17304222
Intra	Shank3	Q9JLU4	Abi1	Rattus norvegicus	Q9QZM5	Imaging	17304222
Intra	Shank3	Q9JLU4	Rps6ka3	Mus musculus	P18654	Y2H	16217014
Intra	Shank3	Q9JLU4	Shank3	Rattus norvegicus	Q9JLU4	Anti Tag CoIP	10433268

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12852	SHANK3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-163345	5-HT7R antagonist 2	Antagonist	/	Unkown
HY-P10106	TAT-PAK18 inhibitory peptide	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Shank3	NCBI	NCBI:85358