Mark2 - microtubule affinity regulating kinase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60328

Summary

Enables protein N-terminus binding activity; protein kinase activity; and Tau Protein binding activity. Involved in several processes, including establishment or maintenance of cell polarity regulating cell shape; generation of neurons; and protein phosphorylation. Located in membrane. Orthologous to human MARK2 (microtubule affinity regulating kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Mark2 Products (2)

mRNA Protein Name
NM_001398633.1 NP_001385562.1 serine/threonine-protein kinase MARK2 isoform 2
NM_021699.3 NP_067731.1 serine/threonine-protein kinase MARK2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14741102 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
14741102 RGD
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
9108484 RGD
enables tau protein binding IPI
IPI: Inferred from physical interaction
24251416 RGD
enables tau-protein kinase activity IDA
IDA: Inferred from direct assay
14517247 RGD
enables tau-protein kinase activity IMP
IMP: Inferred from mutant phenotype
24251416 RGD
Biological Process GO Annotation Evidence References Source
involved in axon development IMP
IMP: Inferred from mutant phenotype
16717194 RGD
involved in establishment or maintenance of cell polarity regulating cell shape IMP
IMP: Inferred from mutant phenotype
16717194 RGD
involved in neuron migration IDA
IDA: Inferred from direct assay
14741102 RGD
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
10542369 RGD
involved in peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
16717194 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
14517247 RGD
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
9108484 RGD
involved in regulation of cytoskeleton organization IDA
IDA: Inferred from direct assay
14517247 RGD
involved in regulation of microtubule cytoskeleton organization IDA
IDA: Inferred from direct assay
10542369 RGD
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
22807451 RGD
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
22807451 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
22807451 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
22807451 RGD
located in membrane IDA
IDA: Inferred from direct assay
14741102 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase MARK2

  • ELKL motif kinase 1

  • EMK-1

  • EMK1

  • MAP/microtubule affinity-regulating kinase 2

  • serine/threonine kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-182743 OICR19451 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mark2 NCBI NCBI:2011