RNASE6 - ribonuclease A family member k6 Gene

Also Known as RAD1; RNS6; RNasek6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6039

About RNASE6

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,781,070-20,782,467 (from NCBI)

This gene has 1 transcript (splice variant), 91 orthologues and 12 paralogues. Broad expression in lymph node (RPKM 33.5), appendix (RPKM 26.6) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014]

RNASE6 Products (1)

mRNA Protein Name
NM_005615.5 NP_005606.1 ribonuclease K6 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA nuclease activity IDA
IDA: Inferred from direct assay
9826755 GOA
Biological Process GO Annotation Evidence References Source
involved in antibacterial humoral response IDA
IDA: Inferred from direct assay
25075772 GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
25075772 GOA
involved in defense response to Gram-negative bacterium IDA
IDA: Inferred from direct assay
25075772 GOA
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
25075772 GOA
NOT involved in defense response to virus IDA
IDA: Inferred from direct assay
9826755 GOA
involved in defense response to virus IDA
IDA: Inferred from direct assay
9826755 GOA
involved in innate immune response IDA
IDA: Inferred from direct assay
25075772 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
25075772 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
25075772 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNASE6 Protein Structure

RnaseA

RnaseA: Pancreatic ribonuclease (29 - 147)

  • 0
  • 100
  • 150 a.a.
Protein Preferred Names Protein Names

ribonuclease K6

  • ribonuclease A D1

Recombinant RNASE6 Proteins

Cat. No. Product Name Accession Purity
HY-P71261 RNASE6 Protein, Human (HEK293, His) Q93091 (W24-L150) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12022 RNASE6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19810 Rnase6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26306 Rnase6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RNASE6 RGD RGD:1303020
Bos taurus RNASE6 VGNC VGNC:33999
Mus musculus RNASE6 MGD MGI:1925666
Macaca mulatta RNASE6 VGNC VGNC:76701
Others RNASE6 NCBI