Siglec15 - sialic acid binding Ig-like lectin 15 Gene

Also Known as Cd33l3; EG620235; SIGLEC-I

Species: Mus musculus

Gene Type: protein coding
Gene ID: 620235

Summary

Acts upstream of or within regulation of actin Cytoskeleton organization; regulation of bone resorption; and regulation of osteoclast development. Located in plasma membrane. Part of protein-containing complex. Orthologous to human SIGLEC15 (sialic acid binding Ig like lectin 15). [provided by Alliance of Genome Resources, Apr 2022]

Siglec15 Products (1)

mRNA Protein Name
NM_001101038.2 NP_001094508.1 sialic acid-binding Ig-like lectin 15 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22451653 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
22451653 MGI
acts upstream of or within regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
22451653 MGI
acts upstream of or within regulation of osteoclast development IGI
IGI: Inferred from genetic interaction
22451653 MGI
acts upstream of or within regulation of osteoclast development IMP
IMP: Inferred from mutant phenotype
22451653 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
22451653 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
22451653 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sialic acid-binding Ig-like lectin 15

  • CD33 molecule-like 3

Recombinant Siglec15 Proteins

Cat. No. Product Name Accession Purity
HY-P70744 Siglec-15 Protein, Mouse (HEK293, His) A7E1W8 (R24-T262) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78208 Siglec-15 Protein, Mouse (Biotinylated, HEK293, His) A7E1W8 (R24-T262) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991364 Aldastotug Inhibitor 99.9% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12902 SIGLEC15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19103 Siglec15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25593 Siglec15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991365 DS-1501 Inhibitor / Unkown
HY-P990505 Anti-Siglec-15/CD33L3 Antibody Inhibitor 98.6674% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Siglec15 NCBI NCBI:284266