SIGLEC15 - sialic acid binding Ig like lectin 15 Gene

Also Known as CD33L3; HsT1361; SIGLEC-15

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 284266

About SIGLEC15

Cytogenetic location: 18q12.3 Genomic coordinates (GRCh38): 18:45,825,675-45,844,094 (from NCBI)

This gene has 5 transcripts (splice variants), 181 orthologues and 16 paralogues. Biased expression in small intestine (RPKM 1.8), duodenum (RPKM 1.0) and 8 other tissues.

Summary

Predicted to be involved in regulation of actin Cytoskeleton organization; regulation of bone resorption; and regulation of osteoclast development. Predicted to be integral component of membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SIGLEC15 Products (1)

mRNA Protein Name
NM_213602.3 NP_998767.1 sialic acid-binding Ig-like lectin 15 precursor

SIGLEC15 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (46 - 164)

Ig_2

Ig_2: Immunoglobulin domain (182 - 250)

  • 0
  • 100
  • 200
  • 300
  • 328 a.a.
Protein Preferred Names Protein Names

sialic acid-binding Ig-like lectin 15

  • CD33 antigen-like 3

Recombinant SIGLEC15 Proteins

Cat. No. Product Name Accession Purity
HY-P70738 Siglec-15 Protein, Human (HEK293, mFc) Q6ZMC9-1 (F20-T263) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70742 Siglec-15 Protein, Human (HEK293, Fc) Q6ZMC9-1 (F20-T263) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70767 Siglec-15 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q6ZMC9-1 (F20-T263) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72475 Siglec-15 Protein, Human (HEK293, His) Q6ZMC9-1 (F20-T263) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78515 Siglec-15 Protein, Human (HEK293, His-Avi) Q6ZMC9-1 (F20-T263) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78910 Siglec-15 Protein, Human (Biotinylated, HEK293, His-Avi) Q6ZMC9-1 (F20-T263) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Chromophobe Renal Cell Carcinoma

  • Chromophobe Adenocarcinoma

  • Chromophobe Carcinoma Of Kidney

  • Kidney Chromophobe

  • Renal Cell Carcinoma, Chromophobe Cell

  • Crcc

  • Chrcc

  • Chromophobe Renal Cell Adenocarcinoma

  • Chromophobe Renal Carcinoma

  • Chromophobe Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991364 Aldastotug Inhibitor 99.9% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12902 SIGLEC15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19103 Siglec15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25593 Siglec15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991365 DS-1501 Inhibitor / Unkown
HY-P990505 Anti-Siglec-15/CD33L3 Antibody Inhibitor 98.6674% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SIGLEC15 RGD RGD:1565948
Mus musculus SIGLEC15 MGD MGI:3646642
Bos taurus SIGLEC15 VGNC VGNC:34618
Felis catus SIGLEC15 VGNC VGNC:65142
Canis familiaris SIGLEC15 VGNC VGNC:46169
Macaca mulatta SIGLEC15 VGNC VGNC:77319
Others SIGLEC15 NCBI