2. Gene
  3. SIGLEC15 - sialic acid binding Ig like lectin 15 Gene

SIGLEC15 - sialic acid binding Ig like lectin 15 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CD33L3; HsT1361; SIGLEC-15

Gene ID: 284266 | Gene type: protein coding

About SIGLEC15

Cytogenetic location: 18q12.3 Genomic coordinates (GRCh38): 18:45,825,675-45,844,094 (from NCBI)

This gene has 5 transcripts (splice variants), 181 orthologues and 16 paralogues. Biased expression in small intestine (RPKM 1.8), duodenum (RPKM 1.0) and 8 other tissues.

Summary

Predicted to be involved in regulation of actin Cytoskeleton organization; regulation of bone resorption; and regulation of osteoclast development. Predicted to be integral component of membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SIGLEC15 Products(1)

mRNA Protein Name
NM_213602.3 NP_998767.1 sialic acid-binding Ig-like lectin 15 precursor

SIGLEC15 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (46 - 164)

Ig_2

Ig_2: Immunoglobulin domain (182 - 250)

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  • 328 a.a.
Protein Preferred Names Protein Names

sialic acid-binding Ig-like lectin 15

CD33 antigen-like 3

Recombinant SIGLEC15 Proteins

Cat. No. Product Name Accession Purity
HY-P70738 Siglec-15 Protein, Human (HEK293, mFc) Q6ZMC9 (F20-T263) ≥95%
HY-P70742 Siglec-15 Protein, Human (HEK293, Fc) Q6ZMC9 (F20-T263) ≥95%
HY-P70767 Siglec-15 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q6ZMC9 (F20-T263) ≥95%
HY-P72475 Siglec-15 Protein, Human (HEK293, His) Q6ZMC9 (F20-T263) ≥95%
HY-P78515 Siglec-15 Protein, Human (HEK293, His-Avi) Q6ZMC9 (F20-T263) ≥95%
HY-P78910 Siglec-15 Protein, Human (Biotinylated, HEK293, His-Avi) Q6ZMC9 (F20-T263) ≥95%

Related Diseases

Diseases Alias
Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma

Chromophobe Carcinoma Of Kidney

Kidney Chromophobe

Renal Cell Carcinoma, Chromophobe Cell

Crcc

Chrcc

Chromophobe Renal Cell Adenocarcinoma

Chromophobe Renal Carcinoma

Chromophobe Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12902 SIGLEC15 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SIGLEC15 RGD RGD:1565948
Mus musculus SIGLEC15 MGD MGI:3646642
Bos taurus SIGLEC15 VGNC VGNC:34618
Felis catus SIGLEC15 VGNC VGNC:65142
Canis familiaris SIGLEC15 VGNC VGNC:46169
Macaca mulatta SIGLEC15 VGNC VGNC:77319
Macaca fascicularis SIGLEC15 NCBI
Others SIGLEC15 NCBI