S100A13 - S100 calcium binding protein A13 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6284

About S100A13

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,618,799-153,634,361 (from NCBI)

This gene has 6 transcripts (splice variants), 162 orthologues and 21 paralogues. Broad expression in heart (RPKM 156.8), fat (RPKM 39.4) and 16 other tissues.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with Other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

S100A13 Products (5)

mRNA Protein Name
NM_001024210.2 NP_001019381.1 protein S100-A13
NM_001024211.2 NP_001019382.1 protein S100-A13
NM_001024212.2 NP_001019383.1 protein S100-A13
NM_001024213.2 NP_001019384.1 protein S100-A13
NM_005979.3 NP_005970.1 protein S100-A13

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables RAGE receptor binding IPI
IPI: Inferred from physical interaction
15033494 GOA
enables calcium ion binding IDA
IDA: Inferred from direct assay
16145699 GOA
enables copper ion binding IDA
IDA: Inferred from direct assay
12746488 GOA
enables fibroblast growth factor binding IPI
IPI: Inferred from physical interaction
11432880 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12746488 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
12746488 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
12118070 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
15033494 GOA
involved in positive regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
20863990 GOA
involved in positive regulation of interleukin-1 alpha production IDA
IDA: Inferred from direct assay
12746488 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15821778 GOA
located in cytosol IDA
IDA: Inferred from direct assay
12746488 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
12746488 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12118070 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
10722710 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A13 Protein Structure

S_100

S_100: S-100/ICaBP type calcium binding domain (9 - 51)

  • 0
  • 98 a.a.
Protein Preferred Names Protein Names

protein S100-A13

S100A13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
S100A13 Q99584 TNF Homo sapiens P01375
Crosslink
36555597
Intra
S100A13 Q99584 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
25416956
Intra
S100A13 Q99584 S100A14 Homo sapiens Q9HCY8
Validated Y2H
32296183
Intra
S100A13 Q99584 S100A14 Homo sapiens Q9HCY8
Y2H Array
32296183
Intra
S100A13 Q99584 S100A14 Homo sapiens Q9HCY8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100A13 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P71271 S100A13 Protein, Human Q99584 (A2-K98) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Trachea Leiomyoma

  • Tracheal Neoplasms

  • Leiomyoma Of The Trachea

  • Tracheal Neoplasm

  • Tracheal Leiomyoma
Conjunctival Intraepithelial Neoplasm

  • Intraepithelial Neoplasia Of Conjunctiva

  • Conjunctival Intraepithelial Neoplasia
Chorioangioma

  • Placental Hemangioma
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12375 S100A13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18725 S100a13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25212 S100a13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus S100A13 VGNC VGNC:34239
Rattus norvegicus S100A13 RGD RGD:1304919
Canis familiaris S100A13 VGNC VGNC:45825
Mus musculus S100A13 MGD MGI:109581
Others S100A13 NCBI