SAG - S-antigen visual arrestin Gene

Homo sapiens

Also known as RP47; S-AG

Gene ID: 6295 | Gene type: protein coding

About SAG

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,307,816-233,347,055 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 259 orthologues, 3 paralogues and is associated with 7 phenotypes. Low expression observed in reference dataset.

Summary

Members of Arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as Hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq, Jul 2008]

SAG Products(1)

mRNA	Protein	Name
NM_000541.5	NP_000532.2	S-arrestin

SAG Protein Structure

Arrestin_N

Arrestin_C

0
100
200
300
405 a.a.

Protein Preferred Names

Protein Names

S-arrestin

48 kDa protein

Recombinant SAG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71781	SAG Protein, Human (P.pastoris, His)	P10523 (M1-E405)	≥95%

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 47

RP47	Retinitis Pigmentosa, Type 47

Oguchi Disease 1

Oguchi Disease-1	CSNBO1
Night Blindness, Congenital Stationary, Oguchi Type 1	Congenital Stationary Night Blindness Oguchi Type 1
Oguchi Disease

Oguchi Disease

Stationary Night Blindness, Oguchi Type	Congenital Stationary Night Blindness, Oguchi Type
Oguchi Syndrome	Oguchis Disease

Oguchi Disease 2

Oguchi Disease-2	CSNBO2
Night Blindness, Congenital Stationary, Oguchi Type 2	Congenital Stationary Night Blindness Oguchi Type 2

Cone Dystrophy

Retinal Cone Dystrophy	Dystrophy, Cone
Cone Dystrophy 3

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Uveitis

Night Blindness

Nyctalopia

Retinal Vasculitis

Posterior Uveitis

Uveitis, Posterior	Choroiditis
Uveitis Posterior

Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary	Congenital Essential Nyctalopia
Oguchi Disease	Blindness, Night, Stationary, Congenital

Eales Disease

Idiopathic Obliterative Vasculopathy	Idiopathic Recurrent Vitreal Hemorrhage
Idiopathic Retinal Perivasculitis	Idiopathic Retinal Vasculitis

Chorioretinitis

Retinochoroiditis

Pineoblastoma

Pineal Pnet	Pinealoma
Pineal Gland Neoplasm	Pineocytoma
Tumor Of The Pineal Region

Pineocytoma

Pinealoma	Pinealocytoma
Pineal Gland Neoplasm	Tumor Of The Pineal Region

Retinal Degeneration

Degeneration Of Retina

Focal Chorioretinitis

Autoimmune Disease Of Eyes, Ear, Nose And Throat

Sympathetic Ophthalmia

Sympathetic Uveitis	Ophthalmia, Sympathetic
Sympathetic Iridocyclitis	Sympathetic Endophthalmitis

Nephrogenic Syndrome Of Inappropriate Antidiuresis

NSIAD

Autoimmune Uveitis

Whim Syndrome 1

Whim Syndrome	Whims
Warts, Hypogammaglobulinemia, Infections, And Myelokathexis	WHIMS1
Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome	Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1
Myelokathexis, Isolated	Wilm
Warts-Infections-Leukopenia-Myelokatexis Syndrome	Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1

Panophthalmitis

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Myasthenic Syndrome, Congenital, 3a, Slow-Channel

Congenital Myasthenic Syndrome 3a	CMS3A
Congenital Myasthenic Syndrome 3a, Slow-Channel	Myasthenic Syndrome, Congenital, Type 3a, Slow-Channel

Diabetes Insipidus

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Birdshot Chorioretinopathy

Birdshot Chorioretinitis	Bscr
Birdshot Retinochoroiditis	Birdshot Retinochoroidopathy
Vitiliginous Choroiditis	Multiple Small, Cream-Colored Lesions, Symmetrically Scattered Mainly Around The Optic Disk

Endophthalmitis

Cerebellar Medulloblastoma

Panuveitis

Diffuse Uveitis	Total Uveitis
Inflammation Of The Whole Uveal Tract

Opioid Abuse

Opioid-Related Disorders

Purulent Endophthalmitis

Periocular Infection	Acute Endophthalmitis
Endophthalmia	Eye Infestation Nos
Intraocular Infection	Eye Infection Nos

Bardet-Biedl Syndrome 5

BBS5	Bardet-Biedl Syndrome, Type 5

Pain Agnosia

Analgesia

Uveal Disease

Uveal Diseases

Agnosia

Dyspraxia	Primary Visual Agnosia
Dyspraxia Syndrome	Monomodal Visual Amnesia
Visual Amnesia	Agnosia, Primary Visual
Apraxias	Alexia

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Pars Planitis

Posterior Cyclitis	Vitritis
Intermediate Uveitis	Peripheral Retinal Inflammation
Uveitis, Intermediate

Choroiditis

Posterior Uveitis

Vogt-Koyanagi-Harada Disease

Uveomeningoencephalitic Syndrome	Uveomenigitic Syndrome
Vogt-Koyanagi-Harada Syndrome	Harada'S Disease
Vogt-Koyanagi Syndrome	Vkh Disease
Vkh Syndrome	Vkh

Neuroretinitis

Juxtapapillary Focal Retinitis And Retinochoroiditis	Retinitis
Focal Retinitis And Retinochoroiditis, Juxtapapillary	Papilloretinitis

Pineal Gland Cancer

Tumor Of The Pineal Region	Malignant Pineal Region Tumor
Malignant Tumor Of Pineal Gland	Neoplasm Of Pineal Gland
Neoplasm Of The Pineal Region	Pineal Body Neoplasm
Pineocytic Tumor	Malignant Neoplasm Of Pineal Gland
Pineal Gland Neoplasm	Pineocytoma

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Anterior Uveitis

Iridocyclitis	Uveitis, Anterior
Acute Anterior Uveitis	Uveokeratitis
Keratouveitis	Cyclitis
Intraocular Inflammation	Kerato-Uveitis
Keratoiritis	Iritis
Uveitis Nos	Uveal Inflammation
Anterior Chamber Cell

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Abnormal Threshold Of Rods

Abnormal Dark Adaptation Curve

Ocular Cancer

Eye Neoplasm	Eye Carcinoma
Eye Cancer	Eye Neoplasms
Malignant Eye Neoplasm	Neoplasm Of Eye
Neoplasm Of Eye Proper	Ocular Tumor
Carcinoma Of Eye	Ocular Carcinoma
Malignant Tumor Of Eye

Nephrogenic Diabetes Insipidus

Vasopressin-Resistant Diabetes Insipidus	Diabetes Insipidus, Nephrogenic
Diabetes Insipidus Nephrogenic	Congenital Nephrogenic Diabetes Insipidus
Adh Resistant Diabetes Insipidus	Diabetes Insipidus Nephrogenic X-Linked
Diabetes Insipidus Nephrogenic Type 1	Adh-Resistant Diabetes Insipidus
Diabetes Insipidus Renalis	Ndi
Renal Diabetes Insipidus	Familial Nephrogenic Diabetes
Antidiuretic-Hormone-Resistant Diabetes Insipidus	Adiuretin-Resistant Diabetes Insipidus
Ndi - [Nephrogenic Diabetes Insipidus]	Diabetes Tenuifluus
Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus	Hereditary Nephrogenic Diabetes Insipidus
Familial Nephrogenic Diabetes Insipidus	Primary Nephrogenic Diabetes Insipidus

Eye Degenerative Disease

Esophageal Adenosquamous Carcinoma

Malignant Secondary Hypertension

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Constipation

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Leber Plus Disease

Leber Congenital Amaurosis	Lca
Leber'S Amaurosis	Leber'S Disease
Amaurosis Congenita Of Leber	Amaurosis Congenita Of Leber, Type 1
Lhon Plus Disease	Congenital Absence Of The Rods And Cones
Congenital Retinal Blindness	Crb
Congenital Amaurosis Of Retinal Origin	Leber'S Congenital Amaurosis
Leber Congenital Amaurosis 1	Leber'S Congenital Tapetoretinal Degeneration
Leber'S Congenital Tapetoretinal Dysplasia	Lca1
Leber Congenital Amaurosis Type 1	Retinal Blindness, Congenital
Amaurosis, Leber Congenital	Dysgenesis Neuroepithelialis Retinae
Hereditary Epithelial Dysplasia Of Retina	Hereditary Retinal Aplasia
Heredoretinopathia Congenitalis	Leber Abiotrophy
Leber Congenital Tapetoretinal Degeneration	Lebers Congenital Amaurosis
Optic Atrophy, Hereditary, Leber

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Related Agents

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12848	SAG	Agonist	99.79%	Unkown
HY-12848B	SAG hydrochloride	Agonist	99.63%	Unkown
HY-12848C	SAG dihydrochloride	Agonist	/	Unkown
HY-117771	DO34	Inhibitor	98.28%	Unkown
HY-124899	Hh-Ag1.5	Agonist	99.97%	Unkown
HY-110240	IHR-1	Antagonist	98.05%	Unkown
HY-12848A	(Rac)-SAG	Agonist	/	Unkown
HY-12848S	SAG-d3	Inhibitor	99.85%	Unkown
HY-157993	SAG-524	Inhibitor	/	Unkown
HY-163455	pan-HCN-IN-1	Inhibitor	/	Unkown
HY-N7001	Dehydrotomatine		/	Unkown
HY-RS12415	SAG Human Pre-designed siRNA Set A		/	Unkown