Actn4 - actinin alpha 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 63836

Summary

Enables protein N-terminus binding activity. Involved in regulation of apoptotic process and response to hypoxia. Located in cytoplasm; neuron projection; and nucleus. Part of protein-containing complex. Colocalizes with stress fiber. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 1. Orthologous to human ACTN4 (actinin alpha 4). [provided by Alliance of Genome Resources, Apr 2022]

Actn4 Products (2)

mRNA Protein Name
NM_031675.2 NP_113863.2 alpha-actinin-4
NM_031675.2 NP_113863.2 alpha-actinin-4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15140894 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
15331416 RGD
enables structural constituent of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
25944910 RGD
enables structural constituent of postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
25944910 RGD
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
10673389 RGD
Biological Process GO Annotation Evidence References Source
involved in regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16014575 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
15942958 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25944910 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25944910 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
20008558 RGD
is active in postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
25944910 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15331416 RGD
located in stress fiber IDA
IDA: Inferred from direct assay
15505042 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-actinin-4

  • F-actin cross-linking protein

  • non-muscle alpha-actinin 4

Actn4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Actn4 Q9QXQ0 Slc2a4 Rattus norvegicus P19357
IF
16396496
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181126 G194-0712 Activator 99.82% Unkown
HY-RS00226 ACTN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20360 Actn4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26869 Actn4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Actn4 NCBI NCBI:81