Slc2a4 - solute carrier family 2 member 4 Gene

Also Known as Glut4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25139

About Slc2a4

Primary_assembly 10: 54,666,015-54,671,565 reverse strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 289 orthologues, 12 paralogues and is associated with 13 phenotypes. Biased expression in Muscle (RPKM 955.), Heart (RPKM 746.4) and 4 other tissues.

Summary

Enables D-glucose transmembrane transporter activity. Involved in several processes, including glucose import in response to Insulin stimulus; regulation of synaptic vesicle budding from presynaptic endocytic zone membrane; and response to ethanol. Acts upstream of or within with a positive effect on long-term memory. Acts upstream of or within with a negative effect on short-term memory. Acts upstream of or within learning or memory and positive regulation of brain-derived neurotrophic factor receptor signaling pathway. Located in several cellular components, including T-tubule; clathrin-coated pit; and cytoplasmic vesicle. Is active in presynapse. Colocalizes with vesicle. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC2A4 (solute carrier family 2 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc2a4 Products (1)

mRNA Protein Name
NM_012751.1 NP_036883.1 solute carrier family 2, facilitated glucose transporter member 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D-glucose transmembrane transporter activity IDA
IDA: Inferred from direct assay
1733237 RGD
enables D-glucose transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
9059504 RGD
enables D-glucose uniporter activity IDA
IDA: Inferred from direct assay
12417639 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16396496 RGD
Biological Process GO Annotation Evidence References Source
involved in D-glucose import IMP
IMP: Inferred from mutant phenotype
20080987 RGD
involved in D-glucose transmembrane transport IDA
IDA: Inferred from direct assay
1733237 RGD
involved in D-glucose transmembrane transport IMP
IMP: Inferred from mutant phenotype
9059504 RGD
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
20868366 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
20868366 RGD
involved in glucose import in response to insulin stimulus IDA
IDA: Inferred from direct assay
2211693 RGD
acts upstream of or within learning or memory IDA
IDA: Inferred from direct assay
27881773 RGD
acts upstream of or within positive effect long-term memory IMP
IMP: Inferred from mutant phenotype
27881773 RGD
acts upstream of or within positive regulation of brain-derived neurotrophic factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
27881773 RGD
involved in regulation of synaptic vesicle budding from presynaptic endocytic zone membrane IDA
IDA: Inferred from direct assay
28111082 RGD
involved in regulation of synaptic vesicle budding from presynaptic endocytic zone membrane IMP
IMP: Inferred from mutant phenotype
28111082 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
18959809 RGD
acts upstream of or within negative effect short-term memory IMP
IMP: Inferred from mutant phenotype
27881773 RGD
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
20868366 RGD
located in cell surface IDA
IDA: Inferred from direct assay
20868366 RGD
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
1881917 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
20080987 RGD
located in endosome IDA
IDA: Inferred from direct assay
12450403 RGD
located in insulin-responsive compartment IDA
IDA: Inferred from direct assay
8366094 RGD
located in multivesicular body IDA
IDA: Inferred from direct assay
1881917 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
9271094 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
20080987 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
28111082 RGD
is active in presynapse IMP
IMP: Inferred from mutant phenotype
28111082 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
1881917 RGD
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
29676955 RGD
located in vesicle IDA
IDA: Inferred from direct assay
11489215 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc2a4 Protein Structure

MFS_GLUT_Class1

MFS_GLUT_Class1: cd17431 (25 - 473)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 509 a.a.
Protein Preferred Names Protein Names

solute carrier family 2, facilitated glucose transporter member 4

  • GLUT-4

  • Glucose transporter 4, insuline-responsive

  • glucose transporter 4 insulin-responsive

  • glucose transporter type 4, insulin-responsive

  • insulin responsive glucose transporter

  • solute carrier family 2 (facilitated glucose transporter), member 4

  • solute carrier family 2 , member 4

Slc2a4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Slc2a4 P19357 Gapdh Rattus norvegicus P04797
Anti Bait CoIP
16396496
Intra
Slc2a4 P19357 Gapdh Rattus norvegicus P04797
Anti Tag CoIP
16396496
Intra
Slc2a4 P19357 Actn4 Rattus norvegicus Q9QXQ0
Anti Tag CoIP
16396496
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13170 SLC2A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13171 Slc2a4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13172 Slc2a4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13173 SLC2A4RG Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc2a4 NCBI NCBI:6517