Perp - PERP, TP53 apoptosis effector Gene

Also Known as THW; KCP1; PIGPC1; KRTCAP1; 1110017A08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 64058

Summary

Acts upstream of or within several processes, including amelogenesis; desmosome organization; and intrinsic apoptotic signaling pathway by p53 class mediator. Located in Golgi apparatus and mitochondrion. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain ventricle and choroid plexus; limb primordium; sensory organ; and skin. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. Orthologous to human PERP (p53 Apoptosis effector related to PMP22). [provided by Alliance of Genome Resources, Apr 2022]

Perp Products (1)

mRNA Protein Name
NM_022032.4 NP_071315.1 p53 apoptosis effector related to PMP-22

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
23117660 MGI
acts upstream of or within amelogenesis IMP
IMP: Inferred from mutant phenotype
21285247 MGI
acts upstream of or within desmosome organization IMP
IMP: Inferred from mutant phenotype
21285247 MGI
acts upstream of or within heterotypic cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
21285247 MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator IDA
IDA: Inferred from direct assay
10733530 MGI
involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
22515648 MGI
involved in positive regulation of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
29740445 MGI
involved in tissue homeostasis IMP
IMP: Inferred from mutant phenotype
22515648 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
10733530 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
25486861 MGI
located in desmosome IDA
IDA: Inferred from direct assay
22515648 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
10733530 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10733530 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

p53 apoptosis effector related to PMP-22

  • KCP-1

  • keratinocyte-associated protein 1

  • p53 apoptosis effector related to Pmp22

  • p53 apoptosis-associated target

Orthologs Information

Species Symbol Source ID
Homo sapiens Perp NCBI NCBI:64065