PRSS22 - serine protease 22 Gene

Also Known as BSSP-4; SP001LA; hBSSP-4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64063

About PRSS22

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,852,730-2,858,170 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 531 orthologues and 17 paralogues. Biased expression in esophagus (RPKM 17.2), stomach (RPKM 8.5) and 11 other tissues.

Summary

This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. [provided by RefSeq, Jul 2008]

PRSS22 Products (1)

mRNA Protein Name
NM_022119.4 NP_071402.1 brain-specific serine protease 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptidase activator activity IDA
IDA: Inferred from direct assay
15701722 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
11602603 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of peptidase activity IDA
IDA: Inferred from direct assay
15701722 GOA
involved in proteolysis IDA
IDA: Inferred from direct assay
11602603 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
11602603 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRSS22 Protein Structure

Trypsin

Trypsin: Trypsin (50 - 285)

  • 0
  • 100
  • 200
  • 300
  • 317 a.a.
Protein Preferred Names Protein Names

brain-specific serine protease 4

  • prosemin

PRSS22 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRSS22 Q9GZN4 PPM1A Homo sapiens P35813
Anti Tag CoIP
33961781
Intra
PRSS22 Q9GZN4 PPM1A Homo sapiens P35813
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRSS22 Proteins

Cat. No. Product Name Accession Purity
HY-P70108 BSSP-4 Protein, Human (HEK293, His) Q9GZN4 (A33-S317) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11250 PRSS22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21178 Prss22 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27695 Prss22 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PRSS22 MGD MGI:1918085
Rattus norvegicus PRSS22 RGD RGD:1310880
Canis familiaris PRSS22 VGNC VGNC:45064
Bos taurus PRSS22 VGNC VGNC:33415
Others PRSS22 NCBI