TINAGL1 - tubulointerstitial nephritis antigen like 1 Gene

Also Known as ARG1; LCN7; LIECG3; TINAGRP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64129

About TINAGL1

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:31,576,515-31,587,686 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues and 12 paralogues. Broad expression in placenta (RPKM 120.0), fat (RPKM 61.8) and 16 other tissues.

Summary

The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

TINAGL1 Products (3)

mRNA Protein Name
NM_001204414.2 NP_001191343.1 tubulointerstitial nephritis antigen-like isoform 2 precursor
NM_001204415.2 NP_001191344.1 tubulointerstitial nephritis antigen-like isoform 3
NM_022164.3 NP_071447.1 tubulointerstitial nephritis antigen-like isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
NOT enables cysteine-type peptidase activity IDA
IDA: Inferred from direct assay
11170462 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in proteolysis IDA
IDA: Inferred from direct assay
11170462 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TINAGL1 Protein Structure

Peptidase_C1

Peptidase_C1: Papain family cysteine protease (203 - 453)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 467 a.a.
Protein Preferred Names Protein Names

tubulointerstitial nephritis antigen-like

  • OLRG-2

TINAGL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TINAGL1 Q9GZM7 KRTAP12-2 Homo sapiens P59991
Validated Y2H
25416956
Intra
TINAGL1 Q9GZM7 TRIP13 Homo sapiens Q15645
Y2H Array
32296183
Intra
TINAGL1 Q9GZM7 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
25416956
Intra
TINAGL1 Q9GZM7 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TINAGL1 Proteins

Cat. No. Product Name Accession Purity
HY-P71369 TINAGL1 Protein, Human (HEK293, His) Q9GZM7-1 (A22-H467) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Colorectal Adenocarcinoma

  • Adenocarcinoma Of Large Intestine
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14543 TINAGL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18727 Tinagl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25214 Tinagl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TINAGL1 VGNC VGNC:35875
Rattus norvegicus TINAGL1 RGD RGD:70956
Macaca mulatta TINAGL1 VGNC VGNC:79184
Canis familiaris TINAGL1 VGNC VGNC:47380
Mus musculus TINAGL1 MGD MGI:2137617
Felis catus TINAGL1 VGNC VGNC:66196
Others TINAGL1 NCBI