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Chp1 - calcineurin-like EF-hand protein 1 Gene

Also Known as Chp; Wrch2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 64152

Summary

Enables calcium ion binding activity; kinase binding activity; and microtubule binding activity. Involved in several processes, including microtubule Cytoskeleton organization; protein stabilization; and regulation of protein modification process. Located in several cellular components, including Golgi membrane; microtubule cytoskeleton; and transport vesicle. Human ortholog(s) of this gene implicated in spastic ataxia. Orthologous to human CHP1 (Calcineurin like EF-hand protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Chp1 Products (1)

mRNA	Protein	Name
NM_024139.2	NP_077053.1	calcineurin B homologous protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	8626580	RGD
enables kinase binding	IDA IDA: Inferred from direct assay	12966074	RGD
enables microtubule binding	IDA IDA: Inferred from direct assay	10512881	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11481038	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cytoplasmic microtubule organization	IDA IDA: Inferred from direct assay	14657246	RGD
involved in membrane docking	IDA IDA: Inferred from direct assay	8626580	RGD
involved in membrane fusion	IDA IDA: Inferred from direct assay	8626580	RGD
involved in membrane organization	IDA IDA: Inferred from direct assay	14657246	RGD
involved in microtubule bundle formation	IDA IDA: Inferred from direct assay	14657246	RGD
involved in negative regulation of protein autophosphorylation	IDA IDA: Inferred from direct assay	12966074	RGD
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	12966074	RGD
involved in negative regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	12966074	RGD
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	21543739	RGD
involved in positive regulation of protein glycosylation	IDA IDA: Inferred from direct assay	21543739	RGD
involved in positive regulation of protein transport	IDA IDA: Inferred from direct assay	21543739	RGD
involved in protein complex oligomerization	IDA IDA: Inferred from direct assay	21543739	RGD
involved in protein export from nucleus	IDA IDA: Inferred from direct assay	14769882	RGD
involved in protein stabilization	IDA IDA: Inferred from direct assay	21543739	RGD
involved in vesicle fusion	IDA IDA: Inferred from direct assay	8626580	RGD
involved in vesicle targeting	IDA IDA: Inferred from direct assay	8626580	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	14657246	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	10512881	RGD
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	14657246	RGD
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	10512881	RGD
located in nucleus	IDA IDA: Inferred from direct assay	14769882	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	21543739	RGD
located in transport vesicle	IDA IDA: Inferred from direct assay	8626580	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
calcineurin B homologous protein 1	EF-hand Ca2+-binding protein p22 EF-hand calcium-binding domain-containing protein p22 calcineurin B-like protein calcineurin homologous protein calcium-binding protein CHP calcium-binding protein p22

Chp1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Chp1	P61023	Gapdh	Rattus norvegicus	P04797	Far-WB	15312048
Intra	Chp1	P61023	Kif1b	Rattus norvegicus	O88658-1	IF	12204119
Intra	Chp1	P61023	Kif1b	Rattus norvegicus	O88658-1	Pull Down	12204119
Intra	Chp1	P61023	Kif1b	Rattus norvegicus	O88658-1	Y2H	12204119
Intra	Chp1	P61023	Stk17b	Rattus norvegicus	Q91XS8	Y2H	21374135
Intra	Chp1	P61023	Stk17b	Rattus norvegicus	Q91XS8	Protein Kinase Assay	12966074
Intra	Chp1	P61023	Stk17b	Rattus norvegicus	Q91XS8	Far-WB	21374135
Cross	Chp1	P61023	GAPDH	Oryctolagus cuniculus	P46406	Pull Down	15312048

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02652	CHP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21312	Chp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27831	Chp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chp1	NCBI	NCBI:11261