Gprc5b - G protein-coupled receptor, family C, group 5, member B Gene

Also Known as Raig2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 64297

Summary

Enables protein kinase binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of neuron differentiation; and positive regulation of signal transduction. Acts upstream of or within several processes, including glucose homeostasis; positive regulation of neuron projection development; and positive regulation of protein kinase activity. Located in cell surface; membrane raft; and plasma membrane. Is expressed in several structures, including alimentary system; brain; brown fat; extraembryonic component; and genitourinary system. Orthologous to human GPRC5B (G protein-coupled receptor class C group 5 member B). [provided by Alliance of Genome Resources, Apr 2022]

Gprc5b Products (2)

mRNA	Protein	Name
NM_001195774.1	NP_001182703.1	G-protein coupled receptor family C group 5 member B isoform 1 precursor
NM_022420.2	NP_071865.1	G-protein coupled receptor family C group 5 member B isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein kinase binding	IPI IPI: Inferred from physical interaction	23169819	MGI
enables protein kinase inhibitor activity	IDA IDA: Inferred from direct assay	23169819	MGI
enables protein kinase inhibitor activity	IGI IGI: Inferred from genetic interaction	23169819	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	23169819	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	21840300	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	23169819	MGI
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	24089469	MGI
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	23169819	MGI
involved in positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	23169819	MGI
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	24089469	MGI
acts upstream of or within positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	20436672	MGI
acts upstream of or within positive regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	23169819	MGI
acts upstream of or within positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	23169819	MGI
involved in positive regulation of protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	23169819	MGI
acts upstream of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	23169819	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	24089469	MGI
is active in membrane raft	IDA IDA: Inferred from direct assay	23169819	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	23169819	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
G-protein coupled receptor family C group 5 member B	RAIG-2 hypothetical protein, clone 2-63 retinoic acid-induced gene 2 protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05750	GPRC5B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19258	Gprc5b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25747	Gprc5b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gprc5b	NCBI	NCBI:51704