GREM2 - gremlin 2, DAN family BMP antagonist Gene

Also Known as PRDC; DAND3; STHAG9; CKTSF1B2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64388

About GREM2

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:240,489,573-240,612,155 (from NCBI)

This gene has 1 transcript (splice variant), 204 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in gall bladder (RPKM 20.4), colon (RPKM 11.9) and 14 other tissues.

Summary

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]

GREM2 Products (1)

mRNA	Protein	Name
NM_022469.4	NP_071914.3	gremlin-2 precursor

GREM2 Protein Structure

DAN

0
100
168 a.a.

Protein Preferred Names	Protein Names
gremlin-2	DAN domain family member 3

Related Diseases

Diseases	Alias
Tooth Agenesis, Selective, 9	STHAG9
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth
Sclerosteosis	Cortical Hyperostosis With Syndactyly Sost Cortical Hyperostosis-Syndactyly Syndrome
Scleral Staphyloma	Scleral Ectasia Staphyloma Of Sclera
Hereditary Mixed Polyposis Syndrome	Hmps
Anodontia	Complete Absence Of Teeth Developmental Absence Of Tooth Total Anodontia Of Permanent And Deciduous Teeth Absence Of Permanent Teeth Anodontia Of Permanent Dentition Agomphiasis Agomphosis Anodontism Complete Developmental Absence Of Teeth Congenital Absence Of Teeth Congenital Complete Absence Of Teeth Congenital Edentia Absence Of Teeth Absent Teeth Congenital Partial Absence Of Teeth Partial Absence Of Teeth Partial Anodontia
Syngnathia	Cleft Palate-Lateral Synechia Syndrome Cpls Syndrome Cleft Palate Lateral Synechia Syndrome
Synostoses, Tarsal, Carpal, And Digital	Calcaneonavicular Coalition Multiple Synostosis Syndrome Synostoses, Tarsal, Carpal And Digital
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Familial Atrial Fibrillation	Atrial Fibrillation, Familial Atfb Atrial Fibrillation Autosomal Dominant Autosomal Dominant Atrial Fibrillation Auricular Fibrillation Atrial Fibrillation Atrial Fibrillation, Familial, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05785	GREM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20945	Grem2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27462	Grem2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GREM2	VGNC	VGNC:41475
Rattus norvegicus	GREM2	RGD	RGD:1560008
Mus musculus	GREM2	MGD	MGI:1344367
Macaca mulatta	GREM2	VGNC	VGNC:106377
Felis catus	GREM2	VGNC	VGNC:107878
Others	GREM2	NCBI