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MFN2 - Mfn2 mitofusin 2 Gene

Also Known as HSG

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 64476

Summary

Enables several functions, including GTP binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including mitochondrion organization; negative regulation of organelle organization; and regulation of Reactive Oxygen Species biosynthetic process. Located in cytosol and mitochondrial outer membrane. Is intrinsic component of mitochondrial outer membrane. Used to study carotid stenosis. Biomarker of several diseases, including artery disease (multiple); fatty liver disease (multiple); obesity; prediabetes syndrome; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; and Charcot-Marie-Tooth disease type 6. Orthologous to human MFN2 (mitofusin 2). [provided by Alliance of Genome Resources, Apr 2022]

MFN2 Products (1)

mRNA	Protein	Name
NM_130894.4	NP_570964.4	mitofusin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTP binding	IMP IMP: Inferred from mutant phenotype	15322553	RGD
enables GTPase binding	IDA IDA: Inferred from direct assay	14561718	RGD
enables GTPase binding	IPI IPI: Inferred from physical interaction	15322553	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	14561718	RGD
enables proteoglycan binding	IPI IPI: Inferred from physical interaction	25151458	RGD
enables small GTPase binding	IDA IDA: Inferred from direct assay	27997345	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to L-glutamate	IEP IEP: Inferred from expression pattern	25416777	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	22703557	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	28518143	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	23658809	RGD
involved in cellular response to ionizing radiation	IEP IEP: Inferred from expression pattern	26415228	RGD
involved in cellular response to low-density lipoprotein particle stimulus	IEP IEP: Inferred from expression pattern	26062420	RGD
involved in cellular response to manganese ion	IEP IEP: Inferred from expression pattern	28232070	RGD
involved in cellular response to mercaptoethanol	IEP IEP: Inferred from expression pattern	26903301	RGD
involved in cellular response to testosterone stimulus	IEP IEP: Inferred from expression pattern	26062420	RGD
involved in intracellular distribution of mitochondria	IMP IMP: Inferred from mutant phenotype	19605646	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	14592431	RGD
involved in mitochondrial calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	25147362	RGD
involved in mitochondrial fusion	IMP IMP: Inferred from mutant phenotype	14561718	RGD
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	18006463	RGD
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	28483668	RGD
involved in negative regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	25017825	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15322553	RGD
involved in negative regulation of cell size	IMP IMP: Inferred from mutant phenotype	27565029	RGD
involved in negative regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	25017825	RGD
involved in negative regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	28478070	RGD
involved in negative regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	28483668	RGD
involved in negative regulation of release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	18006463	RGD
involved in negative regulation of sarcomere organization	IMP IMP: Inferred from mutant phenotype	24777478	RGD
involved in negative regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	15322553	RGD
involved in negative regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	28478070	RGD
involved in positive regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	25034891	RGD
involved in positive regulation of cellular respiration	IMP IMP: Inferred from mutant phenotype	25147362	RGD
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	19605646	RGD
involved in positive regulation of estradiol secretion	IMP IMP: Inferred from mutant phenotype	25120590	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	27997345	RGD
involved in positive regulation of hydrogen peroxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	27997345	RGD
involved in positive regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25034891	RGD
involved in positive regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	18006463	RGD
involved in positive regulation of ovarian follicle development	IMP IMP: Inferred from mutant phenotype	25120590	RGD
involved in positive regulation of progesterone secretion	IMP IMP: Inferred from mutant phenotype	25120590	RGD
involved in positive regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	27997345	RGD
involved in response to D-galactose	IEP IEP: Inferred from expression pattern	28302704	RGD
involved in response to L-arginine	IEP IEP: Inferred from expression pattern	28483572	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	23220115	RGD
involved in response to cadmium ion	IEP IEP: Inferred from expression pattern	25388156	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	25308841	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	26513006	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	25034891	RGD
involved in response to flavonoid	IEP IEP: Inferred from expression pattern	24637344	RGD
involved in response to hypobaric hypoxia	IEP IEP: Inferred from expression pattern	24637344	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	19716857	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	25336449	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	25770118	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	14592431	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	11950885	RGD
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	11950885	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
mitofusin-2	hypertension-related protein mitochondrial transmembrane GTPase FZO1A mitofusin-2-like transmembrane GTPase MFN2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150031	MFI8	Inhibitor	99.67%	Unkown
HY-W187305	MASM7		99.85%	Unkown
HY-126124	AP39		96.35%	Unkown
HY-123985	MFN2 agonist-1	Activator	98.84%	Unkown
HY-W018587	TBPH		95.0%	Unkown
HY-13338	Mabuterol	Agonist	99.96%	Unkown
HY-P4890A	Relaxin H3 (human) TFA		/	Unkown
HY-P4890	Relaxin H3 (human)		/	Unkown
HY-RS08384	MFN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-152051S	Mabuterol-d9 hydrochloride	Agonist	/	Unkown
HY-RS17108	Mfn2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23553	Mfn2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W755295	Mabuterol hydrochloride	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	MFN2	NCBI	NCBI:9927