Fzd4 - frizzled class receptor 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64558

Summary

Enables Wnt-protein binding activity and signaling receptor activity. Involved in Wnt signaling pathway and positive regulation of neuron projection arborization. Predicted to be located in several cellular components, including cell surface; dendrite; and glutamatergic synapse. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (Frizzled class receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Fzd4 Products (1)

mRNA Protein Name
NM_022623.3 NP_072145.1 frizzled-4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
18302287 RGD
enables signaling receptor activity IGI
IGI: Inferred from genetic interaction
25424568 RGD
Biological Process GO Annotation Evidence References Source
involved in Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
25424568 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
25424568 RGD
involved in positive regulation of neuron projection arborization IGI
IGI: Inferred from genetic interaction
25424568 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

frizzled-4

  • frizzled family receptor 4

  • frizzled receptor 4

  • fz-4

  • rFz4

Recombinant Fzd4 Proteins

Cat. No. Product Name Accession Purity
HY-P74142 Frizzled-4/CD344 Protein, Rat (HEK293, His) Q9QZH0/NP_072145.1 (F38-E181) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74143 Frizzled-4/CD344 Protein, Rat (HEK293, Fc) Q9QZH0/NP_072145.1 (F38-E181) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117163 FzM1.8 Agonist 98.93% Unkown
HY-116553 FzM1 Inhibitor 98.72% Unkown
HY-181160 JNK3/Wnt/β-catenin modulator-1 / Unkown
HY-RS05180 FZD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17330 Fzd4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23785 Fzd4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992126 Remigromig Inhibitor 95.25% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fzd4 NCBI NCBI:8322