Unc13a - unc-13 homolog A Gene

Also Known as Unc13h1; Munc13-1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 64829

Summary

Enables several functions, including Calmodulin binding activity; spectrin binding activity; and syntaxin-1 binding activity. Involved in long-term synaptic potentiation; regulated exocytosis; and regulation of synaptic vesicle priming. Located in several cellular components, including Golgi-associated vesicle; presynaptic active zone cytoplasmic component; and presynaptic membrane. Part of protein-containing complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human UNC13A (unc-13 homolog A). [provided by Alliance of Genome Resources, Apr 2022]

Unc13a Products (1)

mRNA	Protein	Name
NM_022861.2	NP_074052.2	protein unc-13 homolog A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SNARE binding	IDA IDA: Inferred from direct assay	18201107	RGD
enables calmodulin binding	IDA IDA: Inferred from direct assay	19492809	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	16732694	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8999968	RGD
enables protein domain specific binding	IDA IDA: Inferred from direct assay	16732694	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	16732694	RGD
enables spectrin binding	IPI IPI: Inferred from physical interaction	9704016	RGD
enables syntaxin binding	IDA IDA: Inferred from direct assay	9895278	RGD
enables syntaxin-1 binding	IDA IDA: Inferred from direct assay	9895278	RGD
enables syntaxin-1 binding	IPI IPI: Inferred from physical interaction	8999968	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in dense core granule priming	IGI IGI: Inferred from genetic interaction	26575293	RGD
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	21849565	RGD
involved in neurotransmitter secretion	IDA IDA: Inferred from direct assay	7559667	RGD
involved in regulation of synaptic vesicle priming	IDA IDA: Inferred from direct assay	21689256	RGD
involved in synaptic vesicle priming	IDA IDA: Inferred from direct assay	21499244	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi-associated vesicle	IDA IDA: Inferred from direct assay	22875941	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	19730411	RGD
located in presynaptic active zone	IDA IDA: Inferred from direct assay	22875941	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	8999968	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	16732694	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	9895278	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein unc-13 homolog A

Unc13a Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Unc13a	Q62768	Stxbp1	Rattus norvegicus	P61765	NMR	22000513
Intra	Unc13a	Q62768	Rims2	Rattus norvegicus	Q9JIS1	X-Ray Diffraction	16732694
Intra	Unc13a	Q62768	Unc13a	Rattus norvegicus	Q62768	X-Ray Diffraction	16732694
Intra	Unc13a	Q62768	Unc13a	Rattus norvegicus	Q62768	Solution Sedimentation	16732694
Intra	Unc13a	Q62768	Rims2	Rattus norvegicus	Q9JIS1	NMR	16732694
Intra	Unc13a	Q62768	Rims2	Rattus norvegicus	Q9JIS1	GMS	16732694
Intra	Unc13a	Q62768	Unc13a	Rattus norvegicus	Q62768	GMS	16732694
Intra	Unc13a	Q62768	Stx1a	Rattus norvegicus	P32851	NMR	22000513
Intra	Unc13a	Q62768	Unc13a	Rattus norvegicus	Q62768	NMR	16732694
Intra	Unc13a	Q62768	Rims2	Rattus norvegicus	Q9JIS1	ITC	16732694

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15464	UNC13A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21216	Unc13a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27732	Unc13a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Unc13a	NCBI	NCBI:23025