Lpar3 - lysophosphatidic acid receptor 3 Gene

Also Known as Edg7; lpA3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 65086

About Lpar3

Chromosome 3: 145,926,718-145,991,941 forward strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 196 orthologues, 18 paralogues and is associated with 7 phenotypes. Biased expression in kidney adult (RPKM 14.3), testis adult (RPKM 9.9) and 11 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and phospholipid binding activity. Involved in gene expression. Acts upstream of or within several processes, including bleb assembly; positive regulation of MAPK cascade; and positive regulation of collateral sprouting. Located in axon. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human LPAR3 (lysophosphatidic acid receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Lpar3 Products (1)

mRNA Protein Name
NM_022983.4 NP_075359.1 lysophosphatidic acid receptor 3

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
22465231 MGI
acts upstream of or within bleb assembly IGI
IGI: Inferred from genetic interaction
17135244 MGI
acts upstream of collateral sprouting IMP
IMP: Inferred from mutant phenotype
22465231 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
20864640 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
15755723 MGI
acts upstream of or within positive regulation of collateral sprouting IMP
IMP: Inferred from mutant phenotype
22465231 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
22465231 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Lpar3 Protein Structure

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (30 - 303)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (31 - 57)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (64 - 89)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (101 - 131)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (144 - 162)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (182 - 211)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (231 - 261)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (271 - 296)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
Protein Preferred Names Protein Names

lysophosphatidic acid receptor 3

  • LPA receptor 3

  • LPA-3

  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7

  • lysophosphatidic acid receptor Edg-7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15706 H2L 5765834 Antagonist 98.66% Unkown
HY-178845 Decyl phosphate Modulator / Unkown
HY-W725737 BrP-LPA Antagonist / Unkown
HY-148291 BrP-LPA sodium Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lpar3 NCBI NCBI:23566