Cldn1 - claudin 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65129

Summary

Predicted to enable identical protein binding activity and virus receptor activity. Involved in several processes, including cellular response to butyrate; cellular response to cytokine stimulus; and endothelial cell development. Located in several cellular components, including apical plasma membrane; bicellular tight junction; and lateral plasma membrane. Biomarker of diabetic retinopathy; liver disease (multiple); non-alcoholic steatohepatitis; and periodontitis. Human ortholog(s) of this gene implicated in Crohn's disease and atopic dermatitis. Orthologous to human CLDN1 (Claudin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cldn1 Products (1)

mRNA Protein Name
NM_031699.3 NP_113887.3 claudin-1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to butyrate IEP
IEP: Inferred from expression pattern
22684624 RGD
involved in cellular response to lead ion IEP
IEP: Inferred from expression pattern
17439918 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
18031476 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
21748286 RGD
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
18768927 RGD
involved in establishment of blood-nerve barrier IMP
IMP: Inferred from mutant phenotype
22733753 RGD
involved in establishment of endothelial intestinal barrier IMP
IMP: Inferred from mutant phenotype
22684624 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
15826721 RGD
involved in positive regulation of bicellular tight junction assembly IMP
IMP: Inferred from mutant phenotype
22684624 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
17897557 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
17889313 RGD
involved in response to interleukin-18 IMP
IMP: Inferred from mutant phenotype
22001439 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
22092031 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
17120308 RGD
involved in xenobiotic transport across blood-nerve barrier IMP
IMP: Inferred from mutant phenotype
22733753 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
22001439 RGD
located in bicellular tight junction IDA
IDA: Inferred from direct assay
11159859 RGD
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
11159859 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

claudin-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990045 Lixudebart Inhibitor 98.88% Phase 2

Pre-clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991200 OM-7D3-B3 Antagonist 97.98% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cldn1 NCBI NCBI:9076