Ruvbl1 - RuvB-like AAA ATPase 1 Gene

Also Known as NMP238; Tip49a; Pontin52

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65137

Summary

Enables 3'-5' DNA helicase activity. Involved in positive regulation of plasminogen activation and regulation of fibroblast apoptotic process. Located in nuclear matrix. Part of protein-containing complex. Orthologous to human RUVBL1 (RuvB like AAA ATPase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ruvbl1 Products (1)

mRNA Protein Name
NM_147177.1 NP_671706.1 ruvB-like 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3'-5' DNA helicase activity IDA
IDA: Inferred from direct assay
10336418 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of plasminogen activation IDA
IDA: Inferred from direct assay
11027681 RGD
involved in regulation of fibroblast apoptotic process IMP
IMP: Inferred from mutant phenotype
12185582 RGD
Cellular Component GO Annotation Evidence References Source
located in nuclear matrix IDA
IDA: Inferred from direct assay
10050036 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
10565543 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ruvB-like 1

  • 49 kDa TATA box-binding protein-interacting protein

  • 49 kDa TBP-interacting protein

  • DNA helicase p50

  • RuvB-like protein 1

  • pontin 52

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114429 CB-6644 Inhibitor 99.85% Unkown
HY-146074 RUVBL1/2 ATPase-IN-1 Inhibitor 99.63% Unkown
HY-103702 TIP48/49-IN-1 99.07% Unkown
HY-183643 RUVBL1/2-IN-1 / Unkown
HY-RS12354 RUVBL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17564 Ruvbl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24024 Ruvbl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ruvbl1 NCBI NCBI:8607