Aacs - acetoacetyl-CoA synthetase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65984

Summary

Enables acetoacetate-CoA Ligase activity and butyrate-CoA Ligase activity. Involved in several processes, including cellular response to glucose stimulus; cellular response to lipid; and positive regulation of Insulin secretion. Located in cytosol. Biomarker of obesity. Orthologous to human AACS (acetoacetyl-CoA synthetase). [provided by Alliance of Genome Resources, Apr 2022]

Aacs Products (1)

mRNA Protein Name
NM_023104.2 NP_075592.1 acetoacetyl-CoA synthetase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables acetoacetate-CoA ligase activity IDA
IDA: Inferred from direct assay
3082367 RGD
enables short-chain fatty acid-CoA ligase activity IDA
IDA: Inferred from direct assay
6539623 RGD
Biological Process GO Annotation Evidence References Source
involved in adipose tissue development IEP
IEP: Inferred from expression pattern
16055091 RGD
involved in cellular response to cholesterol IEP
IEP: Inferred from expression pattern
3663886 RGD
involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
17724028 RGD
involved in cellular response to testosterone stimulus IEP
IEP: Inferred from expression pattern
19085696 RGD
involved in liver development IDA
IDA: Inferred from direct assay
10513626 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
17724028 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
8104400 RGD
involved in response to nutrient IDA
IDA: Inferred from direct assay
3082367 RGD
involved in response to oleic acid IDA
IDA: Inferred from direct assay
2565110 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
3082367 RGD
involved in response to purine-containing compound IEP
IEP: Inferred from expression pattern
6501306 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
33671 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
12034369 RGD
involved in white fat cell differentiation IEP
IEP: Inferred from expression pattern
16055091 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acetoacetyl-CoA synthetase

  • AcAc-CoA ligase

  • acetoacetate-CoA ligase

  • acetoacetyl-CoA ligase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0124 Zonisamide Inhibitor 99.95% Yes
HY-B0124A Zonisamide sodium Inhibitor / Unkown

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-171414 MC-VC-PAB-O-Gemcitabine 99.24% Unkown
HY-14880B Bavisant dihydrochloride hydrate Antagonist 98.07% Yes
HY-161886 SMARCA2-IN-7 Inhibitor / Unkown
HY-161887 SMARCA2-IN-8 Inhibitor / Unkown
HY-B0124S3 Zonisamide-15N,d4 / Unkown
HY-RS00016 AACS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182157 AAC Trimer phosphoramidite / Unkown
HY-B0124S2 Zonisamide-13C6 Inhibitor / Unkown
HY-RS22091 Aacs Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28611 Aacs Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aacs NCBI NCBI:65985