MC-VC-PAB-O-Gemcitabine
Based on 1 Customer Validation
MC-VC-PAB-O-Gemcitabine is a linker-antibiotic intermediate, which is part of the antibody-antibiotic conjugate (AAC) molecule. MC-VC-PAB-O-Gemcitabine is conjugated with the linker and the antibiotic Gemcitabine (HY-17026). MC-VC-PAB-O-Gemcitabine can be used to study the immunotherapy of bacterial infections and the development of new antibacterial drugs.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.24%
- CAS No.: 1639430-82-2
- 화학식: C38H49F2N9O12
- 분자량:861.85
-
보관:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- Protocol
- 순도&문서
- References
-
Help & FAQs
All Antibiotic Isoforms
More
Biological Activity
제품 설명
In Vitro
MC-VC-PAB-O-Gemcitabine (NO.68) can be used to study the immunotherapy of bacterial infections and the development of new antibacterial drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 1639430-82-2
-
Appearance Solid
-
분자량 861.85
-
화학식 C38H49F2N9O12
-
Color White to off-white
-
SMILES
FC1(F)[C@H](O)[C@@H](COC(OCC2=CC=C(C=C2)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN3C(C=CC3=O)=O)=O)=O)=O)=O)O[C@H]1N4C=CC(N)=NC4=O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
용액&용해도
In Vitro:
DMSO : 100 mg/mL (116.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
-
Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
순도&문서
-
Data Sheet (272 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1603 mL | 5.8015 mL | 11.6029 mL | 29.0074 mL |
| 5 mM | 0.2321 mL | 1.1603 mL | 2.3206 mL | 5.8015 mL | |
| 10 mM | 0.1160 mL | 0.5801 mL | 1.1603 mL | 2.9007 mL | |
| 15 mM | 0.0774 mL | 0.3868 mL | 0.7735 mL | 1.9338 mL | |
| 20 mM | 0.0580 mL | 0.2901 mL | 0.5801 mL | 1.4504 mL | |
| 25 mM | 0.0464 mL | 0.2321 mL | 0.4641 mL | 1.1603 mL | |
| 30 mM | 0.0387 mL | 0.1934 mL | 0.3868 mL | 0.9669 mL | |
| 40 mM | 0.0290 mL | 0.1450 mL | 0.2901 mL | 0.7252 mL | |
| 50 mM | 0.0232 mL | 0.1160 mL | 0.2321 mL | 0.5801 mL | |
| 60 mM | 0.0193 mL | 0.0967 mL | 0.1934 mL | 0.4835 mL | |
| 80 mM | 0.0145 mL | 0.0725 mL | 0.1450 mL | 0.3626 mL | |
| 100 mM | 0.0116 mL | 0.0580 mL | 0.1160 mL | 0.2901 mL |
MC-VC-PAB-O-Gemcitabine Related Classifications
HY-171414 Related Classifications
Powered by Bioz