LPAR3 - lysophosphatidic acid receptor 3 Gene

Also Known as Edg7

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 66025

About LPAR3

Primary_assembly 2: 235,149,065-235,193,357 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 196 orthologues and 18 paralogues. Biased expression in Kidney (RPKM 59.9), Lung (RPKM 38.6) and 7 other tissues.

Summary

Enables G-protein alpha-subunit binding activity and phospholipid binding activity. Involved in positive regulation of calcium ion transport and positive regulation of cytosolic calcium ion concentration involved in Phospholipase C-activating G protein-coupled signaling pathway. Predicted to be located in axon. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human LPAR3 (lysophosphatidic acid receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

LPAR3 Products (1)

mRNA Protein Name
NM_023969.2 NP_076459.2 lysophosphatidic acid receptor 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G-protein alpha-subunit binding IMP
IMP: Inferred from mutant phenotype
16504475 RGD
enables phospholipid binding IMP
IMP: Inferred from mutant phenotype
16504475 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16504475 RGD
involved in positive regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
11340076 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPAR3 Protein Structure

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (30 - 303)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (31 - 57)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (64 - 89)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (101 - 131)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (144 - 162)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (182 - 211)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (231 - 261)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (271 - 296)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
Protein Preferred Names Protein Names

lysophosphatidic acid receptor 3

  • LPA receptor 3

  • LPA-3

  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7

  • lysophosphatidic acid receptor Edg-7

  • putative G protein-coupled receptor snGPCR32

  • snGPCR32

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15706 H2L 5765834 Antagonist 98.66% Unkown
HY-178845 Decyl phosphate Modulator / Unkown
HY-W725737 BrP-LPA Antagonist / Unkown
HY-148291 BrP-LPA sodium Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens LPAR3 NCBI NCBI:23566