Klf15 - Kruppel-like factor 15 Gene

Also Known as CKLF; KKLF; hlb444; 1810013I09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66277

Summary

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in cardiac muscle hypertrophy in response to stress; glomerular visceral epithelial cell differentiation; and negative regulation of peptidyl-lysine acetylation. Acts upstream of or within several processes, including cellular glucose homeostasis; positive regulation of glucose import; and response to Insulin. Located in nucleus. Is expressed in several structures, including central nervous system; cranium; early conceptus; metanephros; and nose. Used to study aortic aneurysm. Orthologous to human KLF15 (Kruppel like factor 15). [provided by Alliance of Genome Resources, Apr 2022]

Klf15 Products (2)

mRNA Protein Name
NM_001355668.1 NP_001342597.1 Krueppel-like factor 15 isoform 2
NM_023184.4 NP_075673.1 Krueppel-like factor 15 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12097321 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12097321 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12097321 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
22367544 MGI
Biological Process GO Annotation Evidence References Source
involved in cardiac muscle hypertrophy in response to stress IMP
IMP: Inferred from mutant phenotype
17438289 MGI
acts upstream of or within glial cell differentiation IDA
IDA: Inferred from direct assay
19741146 MGI
acts upstream of or within intracellular glucose homeostasis IDA
IDA: Inferred from direct assay
12097321 MGI
involved in negative regulation of peptidyl-lysine acetylation IMP
IMP: Inferred from mutant phenotype
20375365 MGI
involved in podocyte differentiation IMP
IMP: Inferred from mutant phenotype
22493483 MGI
acts upstream of or within positive regulation of D-glucose import IDA
IDA: Inferred from direct assay
12097321 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12097321 MGI
acts upstream of or within regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
31582141 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
31582141 MGI
involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17438289 MGI
acts upstream of or within response to insulin IDA
IDA: Inferred from direct assay
12097321 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12097321 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Krueppel-like factor 15

  • cardiovascular Krueppel-like factor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07336 KLF15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18393 Klf15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24874 Klf15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Klf15 NCBI NCBI:28999