SNTB1 - syntrophin beta 1 Gene

Homo sapiens

Also known as A1B; SNT2; BSYN2; 59-DAP; DAPA1B; SNT2B1; TIP-43

Gene ID: 6641 | Gene type: protein coding

About SNTB1

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:120,535,756-120,812,046 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 41.8), adrenal (RPKM 32.7) and 22 other tissues.

Summary

Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008]

SNTB1 Products(1)

mRNA	Protein	Name
NM_021021.4	NP_066301.1	beta-1-syntrophin

SNTB1 Protein Structure

PDZ

0
100
200
300
400
500
538 a.a.

Protein Preferred Names

Protein Names

beta-1-syntrophin

59 kDa dystrophin-associated protein A1 basic component 1

Related Diseases

Diseases

Alias

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Muscular Dystrophy, Duchenne Type

Duchenne Muscular Dystrophy	DMD
Muscular Dystrophy, Duchenne	Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type
Severe Dystrophinopathy, Duchenne Type	Muscular Dystrophy Duchenne
Dystrophy, Muscular, Duchenne Type	Benign Duchenne Muscular Dystrophy
Duchenne Motor Neuron Disease	Duchenne Type Dystrophy
Duchenne-Griesinger Disease

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Myopathy

Muscular Diseases

Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13513	SNTB1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SNTB1	VGNC	VGNC:59366
Rattus norvegicus	SNTB1	RGD	RGD:1307728
Canis familiaris	SNTB1	VGNC	VGNC:46613
Macaca mulatta	SNTB1	VGNC	VGNC:77680
Mus musculus	SNTB1	MGD	MGI:101781

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