SNTB1 - syntrophin beta 1 Gene

Also Known as A1B; SNT2; BSYN2; 59-DAP; DAPA1B; SNT2B1; TIP-43

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6641

About SNTB1

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:120,535,756-120,812,046 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 41.8), adrenal (RPKM 32.7) and 22 other tissues.

Summary

Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with Dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two Other structurally-related genes. [provided by RefSeq, Jul 2008]

SNTB1 Products (1)

mRNA	Protein	Name
NM_021021.4	NP_066301.1	beta-1-syntrophin

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7844150	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	18468998	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNTB1 Protein Structure

PDZ

PH

0
100
200
300
400
500
538 a.a.

Protein Preferred Names	Protein Names
beta-1-syntrophin	59 kDa dystrophin-associated protein A1 basic component 1

SNTB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SNTB1	Q13884	DMD	Homo sapiens	P11532	Anti Bait CoIP	7844150
Intra	SNTB1	Q13884	ABCA1	Homo sapiens	O95477	Far-WB	16192269
Intra	SNTB1	Q13884	ABCA1	Homo sapiens	O95477	Peptide Array	16192269

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Muscular Dystrophy, Duchenne Type	Duchenne Muscular Dystrophy DMD Muscular Dystrophy, Duchenne Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type Severe Dystrophinopathy, Duchenne Type Muscular Dystrophy Duchenne Dystrophy, Muscular, Duchenne Type Benign Duchenne Muscular Dystrophy Duchenne Motor Neuron Disease Duchenne Type Dystrophy Duchenne-Griesinger Disease
Myopia	Near-Sightedness Short-Sightedness Nearsightedness Nearsighted Near Vision Close Sighted Myopic Short-Sighted Near Sighted
Myopathy	Muscular Diseases Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13513	SNTB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SNTB1	VGNC	VGNC:59366
Rattus norvegicus	SNTB1	RGD	RGD:1307728
Canis familiaris	SNTB1	VGNC	VGNC:46613
Macaca mulatta	SNTB1	VGNC	VGNC:77680
Mus musculus	SNTB1	MGD	MGI:101781
Others	SNTB1	NCBI