Mtdh - metadherin Gene

Also Known as 3D3; AEG-1; Lyric; 3D3/Lyric; D8Bwg1112e; 2610103J23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67154

Summary

Predicted to enable NF-kappaB binding activity; double-stranded RNA binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of intracellular signal transduction; and regulation of transcription, DNA-templated. Located in endoplasmic reticulum membrane; nucleolus; and perinuclear region of cytoplasm. Is expressed in several structures, including brain; genitourinary system; limb primordium; nose; and skin. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MTDH (metadherin). [provided by Alliance of Genome Resources, Apr 2022]

Mtdh Products (3)

mRNA Protein Name
NM_001357925.1 NP_001344854.1 protein LYRIC isoform 2
NM_001357926.1 NP_001344855.1 protein LYRIC isoform 1
NM_026002.5 NP_080278.3 protein LYRIC isoform 3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19433866 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
14980505 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
19433866 MGI
located in nucleolus IDA
IDA: Inferred from direct assay
14980505 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
14980505 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein LYRIC

  • lysine-rich CEACAM1 co-isolated protein

  • metastasis adhesion protein

Mtdh Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Mtdh Q80WJ7 Snd1 Mus musculus Q78PY7
Anti Tag CoIP
24981741
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-155170 MTDH-SND1 blocker 1 Inhibitor 99.33% Unkown
HY-160801 HKYK-0030 Inhibitor 99.38% Unkown
HY-168850 MTDH-SND1 blocker 2 Inducer 99.51% Unkown
HY-RS08762 MTDH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18775 Mtdh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25263 Mtdh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mtdh NCBI NCBI:92140