Dgat2 - diacylglycerol O-acyltransferase 2 Gene

Also Known as ARAT; DGAT-2; 0610010B06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67800

Summary

Enables 2-acylglycerol O-acyltransferase activity; diacylglycerol O-acyltransferase activity; and protein homodimerization activity. Involved in several processes, including cellular response to oleic acid; diacylglycerol biosynthetic process; and lipid homeostasis. Acts upstream of or within triglyceride biosynthetic process. Located in endoplasmic reticulum; membrane; and perinuclear region of cytoplasm. Is integral component of endoplasmic reticulum membrane. Colocalizes with lipid droplet and mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease. Orthologous to human DGAT2 (diacylglycerol O-acyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Dgat2 Products (1)

mRNA Protein Name
NM_026384.3 NP_080660.1 diacylglycerol O-acyltransferase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 2-acylglycerol O-acyltransferase activity IDA
IDA: Inferred from direct assay
12077311 MGI
enables diacylglycerol O-acyltransferase activity IDA
IDA: Inferred from direct assay
11481335 MGI
enables diacylglycerol O-acyltransferase activity IMP
IMP: Inferred from mutant phenotype
21680734 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
21680734 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to oleic acid IMP
IMP: Inferred from mutant phenotype
21680734 MGI
involved in cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
18252207 MGI
involved in diacylglycerol biosynthetic process IDA
IDA: Inferred from direct assay
23066022 MGI
involved in diacylglycerol metabolic process IDA
IDA: Inferred from direct assay
11481335 MGI
involved in fat pad development IMP
IMP: Inferred from mutant phenotype
18252207 MGI
involved in fatty acid homeostasis IGI
IGI: Inferred from genetic interaction
18252207 MGI
involved in intracellular triglyceride homeostasis IMP
IMP: Inferred from mutant phenotype
14668353 MGI
involved in lipid storage IGI
IGI: Inferred from genetic interaction
21317108 MGI
involved in lipid storage IMP
IMP: Inferred from mutant phenotype
21680734 MGI
involved in long-chain fatty-acyl-CoA metabolic process IDA
IDA: Inferred from direct assay
11481335 MGI
involved in low-density lipoprotein particle clearance IMP
IMP: Inferred from mutant phenotype
18175806 MGI
involved in regulation of plasma lipoprotein particle levels IMP
IMP: Inferred from mutant phenotype
18252207 MGI
acts upstream of or within triglyceride biosynthetic process IDA
IDA: Inferred from direct assay
11481335 MGI
involved in triglyceride biosynthetic process IDA
IDA: Inferred from direct assay
21680734 MGI
acts upstream of or within triglyceride biosynthetic process IMP
IMP: Inferred from mutant phenotype
14668353 MGI
involved in triglyceride biosynthetic process IMP
IMP: Inferred from mutant phenotype
21680734 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
19049983 MGI
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
21680734 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
21680734 MGI
colocalizes with lipid droplet IDA
IDA: Inferred from direct assay
19049983 MGI
located in membrane IDA
IDA: Inferred from direct assay
11481335 MGI
colocalizes with mitochondrion IDA
IDA: Inferred from direct assay
19049983 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19049983 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

diacylglycerol O-acyltransferase 2

  • acyl-CoA retinol O-fatty-acyltransferase

  • diacylglycerol acyltransferase 2

  • diglyceride acyltransferase 2

  • retinol O-fatty-acyltransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153507 DGAT1-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dgat2 NCBI NCBI:84649