Wls - wntless WNT ligand secretion mediator Gene

Also Known as EVI; Gpr177; 5031439A09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68151

Summary

Enables Wnt-protein binding activity. Involved in several processes, including animal organ development; mesoderm formation; and positive regulation of canonical Wnt signaling pathway. Located in Golgi apparatus and cytoplasmic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and skin. Orthologous to human WLS (Wnt ligand secretion mediator). [provided by Alliance of Genome Resources, Apr 2022]

Wls Products (3)

mRNA Protein Name
NM_001356349.1 NP_001343278.1 protein wntless homolog isoform 2 precursor
NM_001356350.1 NP_001343279.1 protein wntless homolog isoform 1
NM_026582.5 NP_080858.3 protein wntless homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Wnt-protein binding IDA
IDA: Inferred from direct assay
19841259 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19841259 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Wnt protein secretion IDA
IDA: Inferred from direct assay
33324648 MGI
involved in Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19841259 MGI
involved in anterior/posterior axis specification IMP
IMP: Inferred from mutant phenotype
19841259 MGI
involved in cementum mineralization IGI
IGI: Inferred from genetic interaction
31059863 MGI
involved in exocrine pancreas development IMP
IMP: Inferred from mutant phenotype
20614471 MGI
involved in hindbrain development IMP
IMP: Inferred from mutant phenotype
20614471 MGI
involved in mesoderm formation IMP
IMP: Inferred from mutant phenotype
19841259 MGI
involved in midbrain development IMP
IMP: Inferred from mutant phenotype
20614471 MGI
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
20614471 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
19841259 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
19841259 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
33324648 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
33324648 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein wntless homolog

  • G protein-coupled receptor 177

  • integral membrane protein GPR177

  • protein evenness interrupted homolog

  • wntless homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15822 WLS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22087 Wls Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28607 Wls Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wls NCBI NCBI:79971