SIK3 - SIK family kinase 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 684112

About SIK3

Primary_assembly 8: 46,311,989-46,522,444 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 224 orthologues, 26 paralogues and is associated with 5 phenotypes. Biased expression in Adrenal (RPKM 87.4), Kidney (RPKM 73.2) and 9 other tissues.

Summary

Predicted to enable ATP binding activity; magnesium ion binding activity; and protein kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of TOR signaling; and protein phosphorylation. Predicted to act upstream of or within endochondral bone morphogenesis; limb morphogenesis; and regulation of protein localization. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human SIK3 (SIK family kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

SIK3 Products (1)

mRNA Protein Name
NM_001271216.2 NP_001258145.2 serine/threonine-protein kinase SIK3

SIK3 Protein Structure

STKc_SIK

STKc_SIK: cd14071 (64 - 316)

UBA_like_SF

UBA_like_SF: cl21463 (345 - 389)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1369 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase SIK3

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-157442 GLPG3312 Inhibitor 98.63% Phase 1

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15776 HG-9-91-01 Inhibitor 99.77% Unkown
HY-101147 YKL-05-099 Inhibitor 99.76% Unkown
HY-120856 ARN-3236 Inhibitor 99.66% Unkown
HY-120877 MRT199665 Inhibitor 99.85% Unkown
HY-N1570 Pterosin B Inhibitor 99.98% Unkown
HY-148061 DB1113 99.86% Unkown
HY-175479 GLPG4970 Inhibitor 99.60% Unkown
HY-139253 MRIA9 Inhibitor 98.88% Unkown
HY-173191 SK-124 Inhibitor 95.0% Unkown
HY-184954 SIK-IN-6 Inhibitor / Unkown
HY-182804 SIK2/3-IN-3 Inhibitor / Unkown
HY-164534 SIK2/3-IN-2 Inhibitor / Unkown
HY-170237 SIK2/3-IN-1 Inhibitor / Unkown
HY-184862 SIK2-IN-5 Inhibitor / Unkown
HY-178014 SIK1-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SIK3 NCBI NCBI:23387