SIK3 - SIK family kinase 3 Gene

Also Known as L19; QSK; SEMDK; SIK-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23387

About SIK3

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:116,843,402-117,098,428 (from NCBI)

This gene has 13 transcripts (splice variants), 224 orthologues, 17 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 19.2), brain (RPKM 13.9) and 25 other tissues.

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of TORC1 signaling; positive regulation of TORC2 signaling; and protein phosphorylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SIK3 Products (22)

mRNA Protein Name
XM_047426671.1 XP_047282627.1 serine/threonine-protein kinase SIK3 isoform X1
NM_001366687.1 NP_001353616.1 serine/threonine-protein kinase SIK3 isoform 5
XM_047426676.1 XP_047282632.1 serine/threonine-protein kinase SIK3 isoform X13
XM_011542723.3 XP_011541025.1 serine/threonine-protein kinase SIK3 isoform X7
XM_005271484.4 XP_005271541.2 serine/threonine-protein kinase SIK3 isoform X5
XM_005271482.5 XP_005271539.2 serine/threonine-protein kinase SIK3 isoform X2
XM_005271485.4 XP_005271542.1 serine/threonine-protein kinase SIK3 isoform X8
NM_001281749.3 NP_001268678.1 serine/threonine-protein kinase SIK3 isoform 3
XM_017017425.2 XP_016872914.1 serine/threonine-protein kinase SIK3 isoform X7
XM_017017426.2 XP_016872915.1 serine/threonine-protein kinase SIK3 isoform X7
NM_025164.6 NP_079440.3 serine/threonine-protein kinase SIK3 isoform 1
XM_047426673.1 XP_047282629.1 serine/threonine-protein kinase SIK3 isoform X9
NM_001366686.3 NP_001353615.1 serine/threonine-protein kinase SIK3 isoform 4
XM_011542724.3 XP_011541026.1 serine/threonine-protein kinase SIK3 isoform X7
XM_047426675.1 XP_047282631.1 serine/threonine-protein kinase SIK3 isoform X12
XM_017017424.2 XP_016872913.1 serine/threonine-protein kinase SIK3 isoform X6
XM_011542725.3 XP_011541027.1 serine/threonine-protein kinase SIK3 isoform X7
NM_001281748.3 NP_001268677.1 serine/threonine-protein kinase SIK3 isoform 2
XM_047426674.1 XP_047282630.1 serine/threonine-protein kinase SIK3 isoform X11
XM_011542722.2 XP_011541024.1 serine/threonine-protein kinase SIK3 isoform X3
XM_047426672.1 XP_047282628.1 serine/threonine-protein kinase SIK3 isoform X4
XM_011542726.2 XP_011541028.1 serine/threonine-protein kinase SIK3 isoform X10

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
14976552 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
14976552 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16306228 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
14976552 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
30232230 GOA
involved in positive regulation of TORC2 signaling IMP
IMP: Inferred from mutant phenotype
30232230 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
14976552 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIK3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (8 - 259)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1263 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase SIK3

  • salt-inducible kinase 3

  • serine/threonine-protein kinase QSK

SIK3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SIK3 Q9Y2K2 YWHAZ Homo sapiens P63104
TAP
16306228
Intra
SIK3 Q9Y2K2 YWHAZ Homo sapiens P63104
Pull Down
16306228
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Advanced Sleep Phase Syndrome

  • Fasps

  • Familial Advanced Sleep-Phase Syndrome

  • Advanced Sleep Phase Syndrome, Familial

  • Familial Advanced Sleep Phase Syndrome

  • Sleep Phase Syndrome, Advanced, Familial

  • Advanced Sleep-Phase Syndrome, Familial
Metaphyseal Chondrodysplasia, Jansen Type

  • Metaphyseal Chondrodysplasia, Murk Jansen Type

  • MCDJ

  • Jansen'S Metaphyseal Chondrodysplasia

  • Murk Jansen Type Metaphyseal Chondrodysplasia

  • Jansen Type Metaphyseal Chondrodysplasia

  • Jansen Disease

  • Jansen Metaphyseal Chondrodysplasia

  • Jansen Metaphyseal Dysostosis

  • Metaphyseal Chondrodysplasia Murk Jansen Type

  • Chondrodysplasia, Metaphyseal, Murk Jansen Type
Spondyloepimetaphyseal Dysplasia

  • Dysplasia, Spondyloepimetaphyseal
Spondyloepimetaphyseal Dysplasia, Krakow Type

  • SEMDK

  • Immunoosseous Dysplasia, Krakow Type
Achromatopsia 3

  • ACHM3

  • Pingelapese Blindness

  • Total Colorblindness With Myopia

  • Achromatopsia With Myopia

  • Achm1

  • Rmch1

  • Rod Monochromacy 1

  • Rod Monochromatism 1

  • Achm1, Formerly

  • Rod Monochromatism 1, Formerly

  • Rod Monochromacy 1, Formerly

  • Rmch1, Formerly

  • Achromatopsia-3

  • Achromatopsia, Type 3
Mesomelia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-157442 GLPG3312 Inhibitor 98.63% Phase 1

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15776 HG-9-91-01 Inhibitor 99.77% Unkown
HY-101147 YKL-05-099 Inhibitor 99.76% Unkown
HY-120877 MRT199665 Inhibitor 99.85% Unkown
HY-120856 ARN-3236 Inhibitor 99.66% Unkown
HY-N1570 Pterosin B Inhibitor 99.98% Unkown
HY-148061 DB1113 99.86% Unkown
HY-139253 MRIA9 Inhibitor 98.88% Unkown
HY-175479 GLPG4970 Inhibitor 99.60% Unkown
HY-173191 SK-124 Inhibitor / Unkown
HY-170237 SIK2/3-IN-1 Inhibitor / Unkown
HY-164534 SIK2/3-IN-2 Inhibitor / Unkown
HY-182804 SIK2/3-IN-3 Inhibitor / Unkown
HY-178014 SIK1-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SIK3 VGNC VGNC:65144
Bos taurus SIK3 VGNC VGNC:34620
Rattus norvegicus SIK3 RGD RGD:1593938
Macaca mulatta SIK3 VGNC VGNC:77330
Mus musculus SIK3 MGD MGI:2446296
Canis familiaris SIK3 VGNC VGNC:46171
Others SIK3 NCBI