Rgmb - repulsive guidance molecule family member B Gene

Also Known as DRAGON; 1110059F19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68799

Summary

Enables identical protein binding activity. Involved in positive regulation of transcription, DNA-templated and signal transduction. Acts upstream of or within BMP signaling pathway and cell adhesion. Located in endoplasmic reticulum-Golgi intermediate compartment. Is anchored component of plasma membrane. Is expressed in several structures, including future brain; gut; nervous system; sensory organ; and skeleton. Orthologous to human RGMB (repulsive guidance molecule BMP co-receptor b). [provided by Alliance of Genome Resources, Apr 2022]

Rgmb Products (6)

mRNA Protein Name
NM_001372256.1 NP_001359185.1 repulsive guidance molecule B isoform 1
NM_001372257.1 NP_001359186.1 repulsive guidance molecule B isoform 1
NM_001372258.1 NP_001359187.1 repulsive guidance molecule B isoform 1
NM_001372259.1 NP_001359188.1 repulsive guidance molecule B isoform 2 precursor
NM_001372292.1 NP_001359221.1 repulsive guidance molecule B isoform 3 precursor
NM_178615.4 NP_848730.2 repulsive guidance molecule B isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
14985445 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
15671031 MGI
acts upstream of or within cell adhesion IDA
IDA: Inferred from direct assay
14985445 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15671031 MGI
involved in signal transduction IDA
IDA: Inferred from direct assay
15671031 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: Inferred from direct assay
14749425 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
14985445 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

repulsive guidance molecule B

  • DRG11-responsive axonal guidance and outgrowth of neurite

  • RGM domain family, member B

Recombinant Rgmb Proteins

Cat. No. Product Name Accession Purity
HY-P77178 RGMB Protein, Mouse (HEK293, His) Q7TQ33/NP_848730.2 (G49-C415) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11895 RGMB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18257 Rgmb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24737 Rgmb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990164 Anti-Mouse RGMb Antibody (307.9D1) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rgmb NCBI NCBI:285704