Cysltr2 - cysteinyl leukotriene receptor 2 Gene

Also Known as Cltr2; Cyslt2; CYSLT2R; 2300001H05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70086

About Cysltr2

Chromosome 14: 73,263,043-73,286,554 reverse strand.GRCm39:CM001007.3

This gene has 5 transcripts (splice variants), 55 orthologues, 13 paralogues and is associated with 18 phenotypes. Broad expression in thymus adult (RPKM 1.4), spleen adult (RPKM .4) and 17 other tissues.

Summary

Enables cysteinyl Leukotriene Receptor activity. Predicted to be involved in several processes, including neuropeptide signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of angiogenesis. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in membrane. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease and asthma. Orthologous to human CYSLTR2 (cysteinyl Leukotriene Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Cysltr2 Products (2)

mRNA Protein Name
NM_001162412.2 NP_001155884.1 cysteinyl leukotriene receptor 2
NM_133720.4 NP_598481.2 cysteinyl leukotriene receptor 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteinyl leukotriene receptor activity IDA
IDA: Inferred from direct assay
11591709 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
11591709 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cysltr2 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (22 - 299)

7tm_GPCRs

7tm_GPCRs: cd14964 (24 - 48)

7tm_GPCRs

7tm_GPCRs: cd14964 (57 - 78)

7tm_GPCRs

7tm_GPCRs: cd14964 (95 - 117)

7tm_GPCRs

7tm_GPCRs: cd14964 (140 - 156)

7tm_GPCRs

7tm_GPCRs: cd14964 (182 - 205)

7tm_GPCRs

7tm_GPCRs: cd14964 (229 - 251)

7tm_GPCRs

7tm_GPCRs: cd14964 (267 - 292)

  • 0
  • 100
  • 200
  • 309 a.a.
Protein Preferred Names Protein Names

cysteinyl leukotriene receptor 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03497 CYSLTR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03498 Cysltr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03499 Cysltr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cysltr2 NCBI NCBI:57105