Steap1 - six transmembrane epithelial antigen of the prostate 1 Gene

Also Known as Steap; Prss24; 2410007B19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70358

Summary

Predicted to enable metal ion binding activity and oxidoreductase activity. Predicted to act upstream of or within ion transport and iron ion homeostasis. Located in endosome and plasma membrane. Is expressed in central nervous system and retina. Orthologous to several human genes including STEAP1 (STEAP family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Steap1 Products (1)

mRNA Protein Name
NM_027399.3 NP_081675.2 metalloreductase STEAP1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables cupric reductase (NADH) activity IDA
IDA: Inferred from direct assay
16609065 MGI
NOT enables ferric-chelate reductase (NADPH) activity IDA
IDA: Inferred from direct assay
16609065 MGI
NOT enables oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor IDA
IDA: Inferred from direct assay
16609065 MGI
Biological Process GO Annotation Evidence References Source
NOT acts upstream of or within copper ion import IDA
IDA: Inferred from direct assay
16609065 MGI
NOT acts upstream of or within iron ion import across cell outer membrane IDA
IDA: Inferred from direct assay
16609065 MGI
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
16609065 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16609065 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metalloreductase STEAP1

  • six-transmembrane epithelial antigen of prostate 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990688 Xaluritamig Inhibitor ≥99% Phase 3

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138632 PROTAC BRD4 Degrader linker conjugate-1 Degrader 98.98% Unkown
HY-RS13905 STEAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13906 STEAP1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16998 Steap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23441 Steap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990673 Vandortuzumab Inhibitor 99.00% Unkown
HY-P99528 Vandortuzumab vedotin 99.52% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Steap1 NCBI NCBI:26872