ICAM5 - intercellular adhesion molecule 5 Gene

Homo sapiens

Also known as TLN; TLCN

Gene ID: 7087 | Gene type: protein coding

About ICAM5

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,289,952-10,296,778 (from NCBI)

This gene has 5 transcripts (splice variants), 91 orthologues and 4 paralogues. Biased expression in brain (RPKM 11.7), lung (RPKM 3.3) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]

ICAM5 Products(1)

mRNA	Protein	Name
NM_003259.4	NP_003250.3	intercellular adhesion molecule 5 precursor

ICAM5 Protein Structure

ICAM_N

Ig_2

Ig_3

Ig_2

0
200
400
600
800
924 a.a.

Protein Preferred Names

Protein Names

intercellular adhesion molecule 5

ICAM-5

Recombinant ICAM5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74869	ICAM-5 Protein, Human (HEK293, His)	Q9UMF0 (E32-P834)	≥95%
HY-P74870	ICAM-5 Protein, Human (570a.a, HEK293, Fc)	Q9UMF0 (E32-E570)	≥95%
HY-P74871	ICAM-5 Protein, Human (132a.a, HEK293, Fc)	Q9UMF0 (E32-Q132)	≥95%

Related Diseases

Diseases

Alias

Acute Flaccid Myelitis

Acute Hemorrhagic Conjunctivitis

Viral Conjunctivitis	Conjunctivitis, Acute Hemorrhagic
Apollo Disease	Epidemic Hemorrhagic Conjunctivitis
Viral Conjunctiva Disorder	Viral Conjunctivitis Nos

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06516	ICAM5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ICAM5	MGD	MGI:109430
Bos taurus	ICAM5	VGNC	VGNC:30025
Felis catus	ICAM5	VGNC	VGNC:67688
Rattus norvegicus	ICAM5	RGD	RGD:1305039
Canis familiaris	ICAM5	VGNC	VGNC:41857
Others	ICAM5	NCBI

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