ICAM5 - intercellular adhesion molecule 5 Gene

Also Known as TLN; TLCN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7087

About ICAM5

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,289,952-10,296,778 (from NCBI)

This gene has 5 transcripts (splice variants), 91 orthologues and 4 paralogues. Biased expression in brain (RPKM 11.7), lung (RPKM 3.3) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]

ICAM5 Products (1)

mRNA Protein Name
NM_003259.4 NP_003250.3 intercellular adhesion molecule 5 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16820411 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ICAM5 Protein Structure

ICAM_N

ICAM_N: Intercellular adhesion molecule (ICAM), N-terminal domain (35 - 122)

Ig_2

Ig_2: Immunoglobulin domain (133 - 202)

Ig_2

Ig_2: Immunoglobulin domain (324 - 392)

Ig_3

Ig_3: Immunoglobulin domain (423 - 474)

Ig_2

Ig_2: Immunoglobulin domain (506 - 569)

Ig_2

Ig_2: Immunoglobulin domain (686 - 741)

Ig_2

Ig_2: Immunoglobulin domain (754 - 827)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 924 a.a.
Protein Preferred Names Protein Names

intercellular adhesion molecule 5

  • ICAM-5

ICAM5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ICAM5 Q9UMF0 KLF5 Homo sapiens Q13887
Validated Y2H
32814053
Intra
ICAM5 Q9UMF0 KLF5 Homo sapiens Q13887
Y2H Array
32814053
Intra
ICAM5 Q9UMF0 KLF5 Homo sapiens Q13887
Y2H Pooling
32814053
Cross
ICAM5 Q9UMF0 ACTN1 Gallus gallus P05094
Pull Down
16820411
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ICAM5 Proteins

Cat. No. Product Name Accession Purity
HY-P74869 ICAM-5 Protein, Human (HEK293, His) Q9UMF0 (E32-P834) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74870 ICAM-5 Protein, Human (539a.a, HEK293, Fc) Q9UMF0 (E32-E570) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P74871 ICAM-5 Protein, Human (101a.a, HEK293, Fc) Q9UMF0 (E32-Q132) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Acute Flaccid Myelitis
Acute Hemorrhagic Conjunctivitis

  • Viral Conjunctivitis

  • Conjunctivitis, Acute Hemorrhagic

  • Apollo Disease

  • Epidemic Hemorrhagic Conjunctivitis

  • Viral Conjunctiva Disorder

  • Viral Conjunctivitis Nos
Holoprosencephaly

  • Holoprosencephaly Sequence

  • Hpe

  • Hpe - [Holoprosencephaly]
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06516 ICAM5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20960 Icam5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27477 Icam5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ICAM5 MGD MGI:109430
Bos taurus ICAM5 VGNC VGNC:30025
Felis catus ICAM5 VGNC VGNC:67688
Rattus norvegicus ICAM5 RGD RGD:1305039
Canis familiaris ICAM5 VGNC VGNC:41857
Others ICAM5 NCBI