TLE4 - TLE family member 4, transcriptional corepressor Gene

Also Known as ESG; BCE1; ESG4; GRG4; BCE-1; Grg-4; E(spI); E(spl)

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7091

About TLE4

Cytogenetic location: 9q21.31 Genomic coordinates (GRCh38): 9:79,571,965-79,726,882 (from NCBI)

This gene has 29 transcripts (splice variants), 257 orthologues and 6 paralogues. Broad expression in testis (RPKM 39.3), bone marrow (RPKM 12.0) and 20 other tissues.

Summary

Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]

TLE4 Products (18)

mRNA Protein Name
NM_001282748.2 NP_001269677.1 transducin-like enhancer protein 4 isoform 1
NM_001282749.2 NP_001269678.1 transducin-like enhancer protein 4 isoform 2
NM_001282753.2 NP_001269682.1 transducin-like enhancer protein 4 isoform 4
NM_001282760.2 NP_001269689.1 transducin-like enhancer protein 4 isoform 5
NM_001351541.2 NP_001338470.1 transducin-like enhancer protein 4 isoform 6
NM_001351542.2 NP_001338471.1 transducin-like enhancer protein 4 isoform 7
NM_001351543.2 NP_001338472.1 transducin-like enhancer protein 4 isoform 8
NM_001351546.2 NP_001338475.1 transducin-like enhancer protein 4 isoform 9
NM_001351547.2 NP_001338476.1 transducin-like enhancer protein 4 isoform 10
NM_001351550.2 NP_001338479.1 transducin-like enhancer protein 4 isoform 11
NM_001351552.2 NP_001338481.1 transducin-like enhancer protein 4 isoform 12
NM_001351556.2 NP_001338485.1 transducin-like enhancer protein 4 isoform 13
NM_001351558.2 NP_001338487.1 transducin-like enhancer protein 4 isoform 14
NM_001351560.2 NP_001338489.1 transducin-like enhancer protein 4 isoform 15
NM_001351562.2 NP_001338491.1 transducin-like enhancer protein 4 isoform 16
NM_001351563.2 NP_001338492.1 transducin-like enhancer protein 4 isoform 17
NM_001351564.2 NP_001338493.1 transducin-like enhancer protein 4 isoform 18
NM_007005.6 NP_008936.2 transducin-like enhancer protein 4 isoform 3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
24676634 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of beta-catenin-TCF complex IDA
IDA: Inferred from direct assay
28296634 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLE4 Protein Structure

TLE_N

TLE_N: Groucho/TLE N-terminal Q-rich domain (8 - 140)

WD40

WD40: WD domain, G-beta repeat (485 - 514)

WD40

WD40: WD domain, G-beta repeat (534 - 561)

WD40

WD40: WD domain, G-beta repeat (573 - 605)

WD40

WD40: WD domain, G-beta repeat (611 - 647)

WD40

WD40: WD domain, G-beta repeat (694 - 728)

WD40

WD40: WD domain, G-beta repeat (742 - 769)

  • 0
  • 200
  • 400
  • 600
  • 773 a.a.
Protein Preferred Names Protein Names

transducin-like enhancer protein 4

  • B lymphocyte gene 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS14566 TLE4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21444 Tle4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27962 Tle4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TLE4 RGD RGD:3868
Felis catus TLE4 VGNC VGNC:97661
Bos taurus TLE4 VGNC VGNC:35892
Mus musculus TLE4 MGD MGI:104633
Canis familiaris TLE4 VGNC VGNC:53997
Others TLE4 NCBI