Aifm2 - apoptosis-inducing factor, mitochondrion-associated 2 Gene

Also Known as Amid; FSP1; PRG3; 5430437E11Rik; D730001I10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 71361

Summary

Predicted to enable several functions, including electron-transferring-flavoprotein dehydrogenase activity; flavin adenine dinucleotide binding activity; and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. Involved in regulation of cellular response to oxidative stress. Located in mitochondrial membrane and nucleus. Is expressed in adrenal medulla; central nervous system; and retina. Orthologous to human AIFM2 (Apoptosis inducing factor mitochondria associated 2). [provided by Alliance of Genome Resources, Apr 2022]

Aifm2 Products (4)

mRNA Protein Name
NM_001039194.3 NP_001034283.1 ferroptosis suppressor protein 1 isoform 2
NM_001284300.1 NP_001271229.1 ferroptosis suppressor protein 1 isoform 2
NM_153779.2 NP_722474.2 ferroptosis suppressor protein 1 isoform 1
NM_178058.4 NP_835159.1 ferroptosis suppressor protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26689472 MGI
Biological Process GO Annotation Evidence References Source
involved in regulation of cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
26689472 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26689472 MGI
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
26689472 MGI
located in nucleus IDA
IDA: Inferred from direct assay
26689472 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ferroptosis suppressor protein 1

  • apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death

  • apoptosis-inducing factor 2

  • apoptosis-inducing factor homologous mitochondrion-associated inducer of death

  • apoptosis-inducing factor-like mitchondrion-associated inducer of

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136057 iFSP1 Activator 99.96% Unkown
HY-RS00493 AIFM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-157744 Coumarin–quinone conjugate 99.9% Unkown
HY-RS17756 Aifm2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24223 Aifm2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aifm2 NCBI NCBI:84883