Tmprss6 - transmembrane serine protease 6 Gene

Also Known as 1300008A22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 71753

Summary

Predicted to enable serine-type endopeptidase activity. Involved in cellular iron ion homeostasis; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within iron ion homeostasis and negative regulation of BMP signaling pathway. Located in plasma membrane. Is expressed in several structures, including cerebral cortex; gut; hemolymphoid system gland; sensory organ; and uterus. Human ortholog(s) of this gene implicated in microcytic anemia. Orthologous to human TMPRSS6 (transmembrane serine protease 6). [provided by Alliance of Genome Resources, Apr 2022]

Tmprss6 Products (2)

mRNA Protein Name
NM_001355601.1 NP_001342530.1 transmembrane protease serine 6 isoform 2
NM_027902.2 NP_082178.2 transmembrane protease serine 6 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of BMP signaling pathway IGI
IGI: Inferred from genetic interaction
19751239 MGI
involved in intracellular iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
25860887 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
19751239 MGI
acts upstream of or within negative regulation of BMP signaling pathway IGI
IGI: Inferred from genetic interaction
19751239 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
25860887 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
25860887 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
12744720 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transmembrane protease serine 6

  • matriptase 2

  • transmembrane protease, serine 6

  • type II transmembrane serine protease 6

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-177662A Sapablursen sodium Inhibitor / Phase 3
HY-177662 Sapablursen Inhibitor 96.05% Phase 2
HY-147278A Manusiran sodium Inhibitor / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991637 Exerenibart Inhibitor 98.00% Phase 2

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-130136A TMPRSS6-IN-1 TFA Inhibitor / Unkown
HY-130136 TMPRSS6-IN-1 Inhibitor / Unkown
HY-147278 Manusiran Inhibitor / Unkown
HY-P11260 MD5 Inhibitor / Unkown
HY-RS14773 TMPRSS6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180217 WGU55 Inhibitor / Unkown
HY-RS19286 Tmprss6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25776 Tmprss6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992451 RLYB331 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tmprss6 NCBI NCBI:164656