Pgam5 - phosphoglycerate mutase family member 5 Gene

Also Known as 2610528A17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72542

Summary

Predicted to enable GTPase activator activity and protein serine/threonine Phosphatase activity. Involved in necroptotic process and negative regulation of cold-induced thermogenesis. Predicted to be located in mitochondrial outer membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Orthologous to human PGAM5 (PGAM family member 5, mitochondrial serine/threonine protein Phosphatase). [provided by Alliance of Genome Resources, Apr 2022]

Pgam5 Products (2)

mRNA Protein Name
NM_001163538.1 NP_001157010.1 serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 1
NM_028273.3 NP_082549.2 serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in necroptotic process IMP
IMP: Inferred from mutant phenotype
22265414 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
27077115 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase PGAM5, mitochondrial

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139598 LFHP-1c Inhibitor 98.01% Unkown
HY-RS10376 PGAM5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17555 Pgam5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24013 Pgam5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pgam5 NCBI NCBI:192111