PGAM5 - PGAM family member 5, mitochondrial serine/threonine protein phosphatase Gene

Also Known as BXLBV68

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 192111

About PGAM5

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:132,710,842-132,722,734 (from NCBI)

This gene has 5 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in esophagus (RPKM 6.8), testis (RPKM 6.7) and 25 other tissues.

Summary

Enables GTPase activator activity and protein serine/threonine Phosphatase activity. Involved in necroptotic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

PGAM5 Products (3)

mRNA	Protein	Name
NM_001170543.2	NP_001164014.1	serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 1
NM_001170544.2	NP_001164015.1	serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 2
NM_138575.4	NP_612642.2	serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	22265414	GOA
enables phosphoprotein phosphatase activity	IMP IMP: Inferred from mutant phenotype	22265414	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19590015	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	19590015	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	22265414	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in necroptotic process	IMP IMP: Inferred from mutant phenotype	22265414	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	22915595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGAM5 Protein Structure

His_Phos_1

0
100
200
289 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein phosphatase PGAM5, mitochondrial	Bcl-XL-binding protein v68

PGAM5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PGAM5	Q96HS1	MAP3K5	Homo sapiens	Q99683	Anti Tag CoIP	19590015

Cross: Cross-species interaction Intra: Intraspecies interaction

PGAM5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87008	PGAM5 Antibody (YA6701)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139598	LFHP-1c	Inhibitor	98.01%	Unkown
HY-RS10376	PGAM5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17555	Pgam5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24013	Pgam5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PGAM5	VGNC	VGNC:100087
Bos taurus	PGAM5	VGNC	VGNC:32780
Mus musculus	PGAM5	MGD	MGI:1919792
Rattus norvegicus	PGAM5	RGD	RGD:1312028
Canis familiaris	PGAM5	VGNC	VGNC:52956
Others	PGAM5	NCBI