Nfatc4 - nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 Gene

Also Known as Nfat3; 3110041H08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 73181

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; long-term memory; and long-term synaptic potentiation. Acts upstream of or within several processes, including circulatory system development; intracellular signal transduction; and negative regulation of cellular component organization. Located in cytosol and nucleus. Part of transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human NFATC4 (nuclear factor of activated T cells 4). [provided by Alliance of Genome Resources, Apr 2022]

Nfatc4 Products (2)

mRNA Protein Name
NM_001168346.1 NP_001161818.1 nuclear factor of activated T-cells, cytoplasmic 4 isoform 2
NM_023699.3 NP_076188.3 nuclear factor of activated T-cells, cytoplasmic 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12796475 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17242187 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
16644691 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12796475 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19538478 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
19538478 MGI
enables transcription factor binding IDA
IDA: Inferred from direct assay
19179536 MGI
Biological Process GO Annotation Evidence References Source
involved in brain-derived neurotrophic factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
22586092 MGI
acts upstream of or within branching involved in blood vessel morphogenesis IGI
IGI: Inferred from genetic interaction
11439183 MGI
acts upstream of or within calcineurin-NFAT signaling cascade IGI
IGI: Inferred from genetic interaction
19179536 MGI
acts upstream of or within cellular respiration IDA
IDA: Inferred from direct assay
12750314 MGI
acts upstream of or within cellular response to UV IGI
IGI: Inferred from genetic interaction
17242187 MGI
acts upstream of or within cellular response to lithium ion IDA
IDA: Inferred from direct assay
20530871 MGI
acts upstream of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
23407945 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
12750314 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IGI
IGI: Inferred from genetic interaction
17242187 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
17242187 MGI
involved in long-term memory IMP
IMP: Inferred from mutant phenotype
22586092 MGI
involved in long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
22586092 MGI
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
21880741 MGI
acts upstream of or within negative regulation of chromatin binding IDA
IDA: Inferred from direct assay
23407945 MGI
acts upstream of or within negative regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
23407945 MGI
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
22586092 MGI
involved in negative regulation of protein binding IDA
IDA: Inferred from direct assay
21880741 MGI
acts upstream of or within negative regulation of synapse maturation IMP
IMP: Inferred from mutant phenotype
23407945 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16644691 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18354019 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
20530871 MGI
acts upstream of or within positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18354019 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16803872 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19538478 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16803872 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17242187 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
17242187 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12796475 MGI
acts upstream of synapse maturation IMP
IMP: Inferred from mutant phenotype
23407945 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17242187 MGI
acts upstream of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
17242187 MGI
acts upstream of or within vascular associated smooth muscle cell development IGI
IGI: Inferred from genetic interaction
11439183 MGI
acts upstream of or within vascular associated smooth muscle cell differentiation IGI
IGI: Inferred from genetic interaction
11439183 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
24970700 MGI
located in cytosol IDA
IDA: Inferred from direct assay
16803872 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11439183 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
20385772 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear factor of activated T-cells, cytoplasmic 4

  • NF-AT3

  • NF-ATc4

  • T-cell transcription factor NFAT3

  • transcription complex subunit NF-ATc4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0254 Kisspeptin-10, human 99.86% Unkown
HY-P0254A Kisspeptin-10, human TFA 99.56% Unkown
HY-N1910 4'-O-Methylbavachalcone Inhibitor 99.64% Unkown
HY-RS09242 NFATC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21899 Nfatc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28416 Nfatc4 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfatc4 NCBI NCBI:4776