UBP1 - upstream binding protein 1 Gene

Homo sapiens

Also known as LBP1A; LBP1B; LBP-1B; LBP-1a

Gene ID: 7342 | Gene type: protein coding

About UBP1

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:33,388,336-33,441,399 (from NCBI)

This gene has 13 transcripts (splice variants), 214 orthologues and 5 paralogues. Ubiquitous expression in lymph node (RPKM 21.9), appendix (RPKM 18.6) and 25 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of viral transcription and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

UBP1 Products(3)

mRNA	Protein	Name
NM_001128160.2	NP_001121632.1	upstream-binding protein 1 isoform LBP-1a
NM_001128161.2	NP_001121633.1	upstream-binding protein 1 isoform LBP-1b
NM_014517.5	NP_055332.3	upstream-binding protein 1 isoform LBP-1b

UBP1 Protein Structure

CP2

0
100
200
300
400
500
540 a.a.

Protein Preferred Names

Protein Names

upstream-binding protein 1

transcription factor LBP-1

Related Diseases

Diseases

Alias

Immunodeficiency 38 With Basal Ganglia Calcification

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Isg15 Deficiency	IMD38
Immunodeficiency 38, Mycobacteriosis, Autosomal Recessive	Immunodeficiency 38
Isg15 Deficiency, Autosomal Recessive	Immunodeficiency 38, With Basal Ganglia Calcification
Autosomal Recessive Isg15 Deficiency	Msmd Due To Complete Isg15 Deficiency
Immunodeficiency, Type 38

Mixed Glioma

Mixed Gliomas	Mixed Neuroglial Tumor
Glioma

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15382	UBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	UBP1	VGNC	VGNC:82712
Mus musculus	UBP1	MGD	MGI:104889
Rattus norvegicus	UBP1	RGD	RGD:1564700
Bos taurus	UBP1	VGNC	VGNC:49155
Canis familiaris	UBP1	VGNC	VGNC:52909
Felis catus	UBP1	VGNC	VGNC:102861
Others	UBP1	NCBI

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