Izumo1 - izumo sperm-egg fusion 1 Gene

Also Known as Izumo; 1700058F15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 73456

Summary

Enables protein binding activity involved in heterotypic cell-cell adhesion; protein homodimerization activity; and signaling receptor binding activity. Involved in fusion of sperm to egg plasma membrane involved in single fertilization; heterotypic cell-cell adhesion; and sperm-egg recognition. Located in acrosomal membrane and plasma membrane. Is integral component of membrane. Orthologous to human IZUMO1 (izumo sperm-egg fusion 1). [provided by Alliance of Genome Resources, Apr 2022]

Izumo1 Products (1)

mRNA Protein Name
NM_001018013.1 NP_001018013.1 izumo sperm-egg fusion protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20421979 MGI
enables protein binding involved in heterotypic cell-cell adhesion IDA
IDA: Inferred from direct assay
35960805 MGI
enables protein binding involved in heterotypic cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
27309808 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
19658160 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
24739963 MGI
Biological Process GO Annotation Evidence References Source
involved in fusion of sperm to egg plasma membrane involved in single fertilization IDA
IDA: Inferred from direct assay
15759005 MGI
involved in fusion of sperm to egg plasma membrane involved in single fertilization IMP
IMP: Inferred from mutant phenotype
24739963 MGI
involved in heterotypic cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
27309808 MGI
involved in single fertilization IMP
IMP: Inferred from mutant phenotype
24739963 MGI
involved in sperm-egg recognition IMP
IMP: Inferred from mutant phenotype
24739963 MGI
Cellular Component GO Annotation Evidence References Source
located in acrosomal membrane IDA
IDA: Inferred from direct assay
19144954 MGI
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
20421979 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
35960805 MGI
located in membrane IDA
IDA: Inferred from direct assay
15759005 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
35960805 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
27624483 MGI
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
27309808 MGI
part of protein complex involved in cell-cell adhesion IDA
IDA: Inferred from direct assay
31672133 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

izumo sperm-egg fusion protein 1

  • OBF

  • oocyte binding/fusion factor

  • sperm-specific protein Izumo

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07004 IZUMO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07005 IZUMO1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19263 Izumo1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21242 Izumo1r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25752 Izumo1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27759 Izumo1r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Izumo1 NCBI NCBI:284359