VIPR1 - vasoactive intestinal peptide receptor 1 Gene

Also Known as II; HVR1; RDC1; V1RG; VIPR; VIRG; VAPC1; VPAC1; VPAC1R; VIP-R-1; VPCAP1R; PACAP-R2; PACAP-R-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7433

About VIPR1

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:42,489,299-42,537,568 (from NCBI)

This gene has 17 transcripts (splice variants), 194 orthologues and 42 paralogues. Broad expression in lung (RPKM 17.1), duodenum (RPKM 12.7) and 17 other tissues.

Summary

This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates Adenylate Cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

VIPR1 Products (5)

mRNA	Protein	Name
NM_001251882.2	NP_001238811.1	vasoactive intestinal polypeptide receptor 1 isoform 2
NM_001251883.2	NP_001238812.1	vasoactive intestinal polypeptide receptor 1 isoform 3
NM_001251884.2	NP_001238813.1	vasoactive intestinal polypeptide receptor 1 isoform 4
NM_001251885.2	NP_001238814.1	vasoactive intestinal polypeptide receptor 1 isoform 5
NM_004624.4	NP_004615.2	vasoactive intestinal polypeptide receptor 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	8390245	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23597562	GOA
enables vasoactive intestinal polypeptide receptor activity	IDA IDA: Inferred from direct assay	8390245	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IDA IDA: Inferred from direct assay	8390245	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VIPR1 Protein Structure

HRM

7tm_2

0
100
200
300
400
457 a.a.

Protein Preferred Names	Protein Names
vasoactive intestinal polypeptide receptor 1	PACAP type II receptor

VIPR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VIPR1	P32241	PRDM5	Homo sapiens	Q9NQX1-2	Y2H Prey Pooling	32296183
Intra	VIPR1	P32241	PRDM5	Homo sapiens	Q9NQX1-2	Validated Y2H	32296183
Intra	VIPR1	P32241	PRDM5	Homo sapiens	Q9NQX1-2	Y2H Array	32296183
Intra	VIPR1	P32241	P01282-PRO_0000011460	Homo sapiens	P01282-PRO_0000011460	SPA	23597562

Cross: Cross-species interaction Intra: Intraspecies interaction

VIPR1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81524	VIPR1 Antibody (YA1269)	IHC-P	Human
HY-P81524A	VIPR1 Antibody (YA1269)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Achalasia	Cardiospasm Achalasia Of Cardia Esophageal Achalasia Hypertensive Lower Esophageal Sphincter Idiopathic Achalasia Achalasia Cardia Idiopathic Achalasia Of Esophagus Primary Achalasia Achalasia Of Esophagus Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter Aperistalsis Of The Oesophagus Achalasia Of Oesophagus Oesophageal Achalasia Achalasia Nos Cardia Spasm Cardia Achalasia Oesophageal Cardiospasm Oesophagus Achalasia Reflex Cardiospasm
Gastric Leiomyoma	Leiomyoma Of The Stomach
Parkinson Disease 14, Autosomal Recessive	PARK14 Dystonia-Parkinsonism, Adult-Onset Autosomal Recessive Parkinson Disease 14 Parkinson'S Disease 14 Dystonia-Parkinsonism Adult-Onset Adult-Onset Dystonia-Parkinsonism Dystonia-Parkinsonism, Paisan-Ruiz Type Pla2g6-Related Dystonia-Parkinsonism Parkinson Disease 14 Autosomal Recessive Parkinson'S Disease 14 Nbia/Dyt/Park-Pla2g6 Dystonia-Parkinsonism Paisan-Ruiz Type Parkinson Disease 14 Autosomal Recessive Parkinson Disease, Type 14
Shigellosis	Dysentery, Bacillary Bacillary Dysentery Shigella Boydii Infectious Disease Shigella Flexneri Infectious Disease Shigella Gastroenteritis Shigella Sonnei Infectious Disease Shigella Infections
Tremor, Hereditary Essential, 2	ETM2 Essential Tremor 2 Essential Tremor, Hereditary, 2 Hereditary Essential Tremor 2 Tremor Hereditary Essential, 2
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Sudden Infant Death Syndrome	SIDS Sudden Infant Death Syndrome, Susceptibility To Cot Death Crib Death Sudden Death Of Nonspecific Cause In Infancy Sudden Infant Death Death, Sudden, Syndrome, Infant
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15655	VIPR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22914	Vipr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29428	Vipr1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	VIPR1	RGD	RGD:3961
Mus musculus	VIPR1	MGD	MGI:109272
Bos taurus	VIPR1	VGNC	VGNC:36799
Canis familiaris	VIPR1	VGNC	VGNC:48265
Felis catus	VIPR1	VGNC	VGNC:66945
Macaca mulatta	VIPR1	VGNC	VGNC:78771
Others	VIPR1	NCBI