Nme5 - NME/NM23 family member 5 Gene

Also Known as Nm23-M5; 1700019D05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 75533

Summary

Predicted to enable nucleoside diphosphate kinase activity. Involved in spermatid development. Acts upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and ventricular system development. Located in sperm flagellum. Is expressed in lung epithelium; nasal cavity respiratory epithelium; and nasopharynx epithelium. Used to study hydrocephalus. Orthologous to human NME5 (NME/NM23 family member 5). [provided by Alliance of Genome Resources, Apr 2022]

Nme5 Products (1)

mRNA Protein Name
NM_080637.4 NP_542368.2 nucleoside diphosphate kinase homolog 5

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
21746835 MGI
acts upstream of or within epithelial cilium movement involved in extracellular fluid movement IMP
IMP: Inferred from mutant phenotype
21746835 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
21746835 MGI
acts upstream of or within negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
12788088 MGI
involved in spermatid development IDA
IDA: Inferred from direct assay
12788088 MGI
acts upstream of or within spermatid development IMP
IMP: Inferred from mutant phenotype
19303412 MGI
acts upstream of or within ventricular system development IMP
IMP: Inferred from mutant phenotype
21746835 MGI
Cellular Component GO Annotation Evidence References Source
located in 9+2 motile cilium IDA
IDA: Inferred from direct assay
32203505 MGI
part of radial spoke IDA
IDA: Inferred from direct assay
36417862 MGI
located in sperm flagellum IDA
IDA: Inferred from direct assay
19303412 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleoside diphosphate kinase homolog 5

  • NDK-H 5

  • NDP kinase homolog 5

  • expressed in non-metastatic cells 5

  • non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)

  • rsph23

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09376 NME5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22261 Nme5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28783 Nme5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nme5 NCBI NCBI:8382